Structure of PDB 5m5e Chain B Binding Site BS03

Receptor Information

>5m5e Chain B (length=203) Species: 9606 (Homo sapiens)

SQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQ
ASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLR
LMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEA
PLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRT
KPA

Ligand information

• Ligand ID: CYS
• InChI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1
• InChIKey: XUJNEKJLAYXESH-REOHCLBHSA-N
• SMILES:
  CACTVS 3.341: N[CH](CS)C(O)=O
  OpenEye OEToolkits 1.5.0: C([C@@H](C(=O)O)N)S
  CACTVS 3.341: N[C@@H](CS)C(O)=O
  ACDLabs 10.04: O=C(O)C(N)CS
  OpenEye OEToolkits 1.5.0: C(C(C(=O)O)N)S
• Formula: C3 H7 N O2 S
• Name: CYSTEINE
• ChEMBL: CHEMBL863
• DrugBank: DB00151
• ZINC: ZINC000000895042
• PDB chain: 5m5e Chain B Residue 312

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5m5e Cergutuzumab amunaleukin (CEA-IL2v), a CEA-targeted IL-2 variant-based immunocytokine for combination cancer immunotherapy: Overcoming limitations of aldesleukin and conventional IL-2-based immunocytokines.
• Resolution: 2.3 Å
• Binding residue (original residue number in PDB): H116 E118 N123 C168
• Binding residue (residue number reindexed from 1): H111 E113 N118 C163
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0004896 cytokine receptor activity

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:5m5e, PDBe:5m5e, PDBj:5m5e
• PDBsum: 5m5e
• PubMed: 28405498
• UniProt: P14784|IL2RB_HUMAN Interleukin-2 receptor subunit beta (Gene Name=IL2RB)