Structure of PDB 5kl8 Chain B Binding Site BS03

Receptor Information
>5kl8 Chain B (length=69) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SRHCVFCENNNEPEAVINSHSVRDNFNRVLCPKLRTYVCPICGASGDSAH
TIKYCPKKPIITMEDAIKA
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5kl8 Chain B Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5kl8 Drosophila Nanos acts as a molecular clamp that modulates the RNA-binding and repression activities of Pumilio.
Resolution4.0 Å
Binding residue
(original residue number in PDB)		C354 C357 H365 C370
Binding residue
(residue number reindexed from 1)		C39 C42 H50 C55
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:5kl8, PDBe:5kl8, PDBj:5kl8
PDBsum5kl8
PubMed27482653
UniProtP25724|NANOS_DROME Protein nanos (Gene Name=nanos)

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