Structure of PDB 5jk6 Chain B Binding Site BS03

Receptor Information
>5jk6 Chain B (length=389) Species: 44689 (Dictyostelium discoideum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QSYHSSIFFSISKGSDKIGGLLEYLEIIKKHNINITRIESRPSKTEKKDY
DFFLDLEYPTENNKEVEKVIKDLEEKGVKATTLQESSNQTYAPWFPRKIS
DLDLFANKPGASDPVYRERRREIAKIASTYKHGDEIPRIDYTEEEIKTWG
VVYNRLKELFPTNACHQHAYIFPLLEQNCGYSPDNIPQLQDISNFLQECT
GWRIRPVQGLLSARDFLNGLAFRVFHATQYIRHPSVPLYTPEPDCCHELL
GHVPLLADPDFADFSQEIGLASIGASDEDIQLLSTCYWFTVEFGLCKEGD
TIRAYGAGILSSTGEMEHFLTDKAKKLPFNPFDACNTEYPITTFQPLYYV
AESFQKAKEQMRQFADSFKKPFSIRYNPYTQSIEILDNK
Ligand information
Ligand IDFE
InChIInChI=1S/Fe/q+3
InChIKeyVTLYFUHAOXGGBS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Fe+3]
FormulaFe
NameFE (III) ION
ChEMBL
DrugBankDB13949
ZINC
PDB chain5jk6 Chain B Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5jk6 Phenylalanine hydroxylase from dictyostelium - apo form
Resolution2.072 Å
Binding residue
(original residue number in PDB)		H273 H278 E318
Binding residue
(residue number reindexed from 1)		H247 H252 E292
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H273 H278 E318 S337
Catalytic site (residue number reindexed from 1) H247 H252 E292 S311
Enzyme Commision number 1.14.16.1: phenylalanine 4-monooxygenase.
1.14.16.4: tryptophan 5-monooxygenase.
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0004505 phenylalanine 4-monooxygenase activity
GO:0004510 tryptophan 5-monooxygenase activity
GO:0004664 prephenate dehydratase activity
GO:0005506 iron ion binding
GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
GO:0034617 tetrahydrobiopterin binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006559 L-phenylalanine catabolic process
GO:0006571 tyrosine biosynthetic process
GO:0009072 aromatic amino acid metabolic process
GO:0009094 L-phenylalanine biosynthetic process
GO:0019293 tyrosine biosynthetic process, by oxidation of phenylalanine
GO:0019954 asexual reproduction
Cellular Component
GO:0005575 cellular_component

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5jk6, PDBe:5jk6, PDBj:5jk6
PDBsum5jk6
PubMed
UniProtQ54XS1|PH4H_DICDI Phenylalanine-4-hydroxylase (Gene Name=pah)

[Back to BioLiP]