Structure of PDB 5edv Chain B Binding Site BS03

Receptor Information
>5edv Chain B (length=333) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
CAVCGWALPHNRMQALTSCECTICPDCFRQHFTIALKEKHITDMVCPACG
RPDLTDSYFSTLDIQLRESLEPDAYALFHKKLTEGVLMRDPKFLWCAQCS
FGFIYEREQLEATCPQCHQTFCVRCKRQWEEQHRGRSCEDFQNWKRMNDP
EYQAQGLAMYLQENGIDCPKCKFSYALARGGCMHFHCTQCRHQFCSGCYN
AFYAKNKCPEPNCRVKKSLHGHHPRDCLFYLRDWTALRLQKLLQDNNVMF
NTEPGGCRVIEQKEVPNGLRDEACGKETPAGYAGLCQAHYKEYLVSLINA
HSLTLYEVEELETATERYLHLQKLTEEVPLGQS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5edv Chain B Residue 2003 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5edv Structure of a HOIP/E2~ubiquitin complex reveals RBR E3 ligase mechanism and regulation.
Resolution3.48 Å
Binding residue
(original residue number in PDB)		C799 C802 C817 C820
Binding residue
(residue number reindexed from 1)		C96 C99 C114 C117
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.31: RBR-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0008270 zinc ion binding
Cellular Component
GO:0071797 LUBAC complex

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:5edv, PDBe:5edv, PDBj:5edv
PDBsum5edv
PubMed26789245
UniProtQ96EP0|RNF31_HUMAN E3 ubiquitin-protein ligase RNF31 (Gene Name=RNF31)

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