Structure of PDB 4z4q Chain B Binding Site BS03

Receptor Information
>4z4q Chain B (length=708) Species: 170187 (Streptococcus pneumoniae TIGR4) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAK
AKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDADTDGAHI
QTLLLTFFYRYMRPLVEAGHVYIALPPLYKMSKGKGKKEEVAYAWTDGEL
EELRKQFGKGATLQRYKGLGEMNADQLWETTMNPETRTLIRVTIEDLARA
ERRVNVLMGDKVEPRRKWIEDNVKFTNIQNMSLEDIMGERFGRYSKYIIQ
DRALPDIRDGLKPVQRRILYSMNKDSNTFDKSYRKSAKSVGNIMGNFHPH
GDSSIYDAMVRMSQNWKNREILVEMHGNNGSMDGDPPAAMRYTEARLSEI
AGYLLQDIEKKTVPFAWNFDDTEKEPTVLPAAFPNLLVNGSTGISAGYAT
DIPPHNLAEVIDAAVYMIDHPTAKIDKLMEFLPGPDFPTGAIIQGRDEIK
KAYETGKGRVVVRSKTEIEKLKGGKEQIVITEIPYEINKANLVKKIDDVR
VNNKVAGIAEVRDESDRDGLRIAIELKKDANTELVLNYLFKYTDLQINYN
FNMVAIDNFTPRQVGIVPILSSYIAHRREVILARSRFDKEKAEKRLHIVE
GLIRVISILDEVIALIRASENKADAKENLKVSYDFTEEQAEAIVTLQLYR
LTNTDVVVLQEEEAELREKIAMLAAIIGDERTMYNLMKKELREVKKKFAT
PRLSSLED
Ligand information
Receptor-Ligand Complex Structure
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PDB4z4q Structural studies of the drug-stabilized cleavage complexes of topoisomerase IV and gyrase from Streptococcus pneumoniae
Resolution3.04 Å
Binding residue
(original residue number in PDB)		K458 I460 N461 K464 N473 H513 V626 R629 Y1118 I1170 S1171 G1173 Y1174 A1175 R1235
Binding residue
(residue number reindexed from 1)		K44 I46 N47 K50 N59 H99 V212 R215 Y342 I394 S395 G397 Y398 A399 R459
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change
Cellular Component
GO:0005694 chromosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4z4q, PDBe:4z4q, PDBj:4z4q
PDBsum4z4q
PubMed
UniProtP72525|PARC_STRPN DNA topoisomerase 4 subunit A (Gene Name=parC);
Q59961|PARE_STRPN DNA topoisomerase 4 subunit B (Gene Name=parE)

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