Structure of PDB 4z31 Chain B Binding Site BS03
Receptor Information
>4z31 Chain B (length=295) Species:
9606
(Homo sapiens) [
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NLGENKHYEVAKKCVEDLALYLKALSRPMQRKLVTLVNCQLVEEEGRVRA
MRAARSLGERTVTELILQHQNPQQLSANLWAAVRARGCQFLGPAMQEEAL
KLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKTSIGHVVQLLYRASC
FKVTKRDEDSSLMQLKEEFRSYEALRREHDAQIVHIAMEAGLRISPEQWS
SLLYGDLAHKSHMQSIIDKLQSPESFAKSVQELTIVLQRTGDPANLNRLR
PHLELLANIDPNPDAVSPTWEQLENAMVAVKTVVHGLVDFIQNYS
Ligand information
>4z31 Chain E (length=15) [
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auguucugugaacac
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Receptor-Ligand Complex Structure
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PDB
4z31
New Insights into the RNA-Binding and E3 Ubiquitin Ligase Activities of Roquins.
Resolution
2.5 Å
Binding residue
(original residue number in PDB)
R185 R216 S235 T237 Q244 Y247 R248 D260 S261 S262
Binding residue
(residue number reindexed from 1)
R84 R115 S134 T136 Q143 Y146 R147 D159 S160 S161
Binding affinity
PDBbind-CN
: Kd=356nM
Enzymatic activity
Enzyme Commision number
2.3.2.27
: RING-type E3 ubiquitin transferase.
External links
PDB
RCSB:4z31
,
PDBe:4z31
,
PDBj:4z31
PDBsum
4z31
PubMed
26489670
UniProt
Q9HBD1
|RC3H2_HUMAN Roquin-2 (Gene Name=RC3H2)
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