Structure of PDB 4uox Chain B Binding Site BS03

Receptor Information
>4uox Chain B (length=452) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ASALACSAHALNLIEKRTLDHEEMKALNREVIEYFKEHVNPGFLEYRKSV
TAGGDYGAVEWQAGSLNTLVDTQGQEFIDCLGGFGIFNVGHRNPVVVSAV
QNQLAKQPLHSQELLDPLRAMLAKTLAALTPGKLKYSFFCNSGTESVEAA
LKLAKAYQSPRGKFTFIATSGAFHGKSLGALSATAKSTFRKPFMPLLPGF
RHVPFGNIEAMRTALNECKKTGDDVAAVILEPIQGEGGVILPPPGYLTAV
RKLCDEFGALMILDEVQTGMGRTGKMFACEHENVQPDILCLAKALGGGVM
PIGATIATEEVFSVLFDNPFLHTTTFGGNPLACAAALATINVLLEQNLPA
QAEQKGDMLLDGFRQLAREYPDLVQEARGKGMLMAIEFVDNEIGYNFASE
MFRQRVLVAGTLNNAKTIRIEPPLTLTIEQCELVIKAARKALAAMRVSVE
EA
Ligand information
Ligand IDPUT
InChIInChI=1S/C4H12N2/c5-3-1-2-4-6/h1-6H2
InChIKeyKIDHWZJUCRJVML-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(CCN)CN
ACDLabs 10.04
CACTVS 3.341		NCCCCN
FormulaC4 H12 N2
Name1,4-DIAMINOBUTANE;
PUTRESCINE
ChEMBLCHEMBL46257
DrugBankDB01917
ZINCZINC000005828633
PDB chain4uox Chain B Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4uox Structure of Putrescine Aminotransferase from Escherichia Coli Provides Insights Into the Substrate Specificity Among Class III Aminotransferases.
Resolution2.085 Å
Binding residue
(original residue number in PDB)		F91 E243
Binding residue
(residue number reindexed from 1)		F84 E236
Annotation score5
Enzymatic activity
Catalytic site (original residue number in PDB) F50 F180 E238 D271 Q274 K300 T332 R426
Catalytic site (residue number reindexed from 1) F43 F173 E231 D264 Q267 K293 T325 R419
Enzyme Commision number 2.6.1.29: diamine transaminase.
2.6.1.82: putrescine--2-oxoglutarate transaminase.
Gene Ontology
Molecular Function
GO:0008483 transaminase activity
GO:0019161 diamine transaminase activity
GO:0030170 pyridoxal phosphate binding
GO:0033094 putrescine--2-oxoglutarate transaminase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0009447 putrescine catabolic process
GO:0019477 L-lysine catabolic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4uox, PDBe:4uox, PDBj:4uox
PDBsum4uox
PubMed25423189
UniProtP42588|PAT_ECOLI Putrescine aminotransferase (Gene Name=patA)

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