Structure of PDB 4o6a Chain B Binding Site BS03
Receptor Information
>4o6a Chain B (length=358) Species:
10090
(Mus musculus) [
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KLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTG
SYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFKRIPRGNPL
SHFLEGEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLI
RNPEEISVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLV
PKNAKDGNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECL
KLMKYLLEQLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSC
FDKLLAFFLECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERN
NGFPIFDK
Ligand information
>4o6a Chain C (length=17) [
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aaattgccgaagacgaa
Receptor-Ligand Complex Structure
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PDB
4o6a
The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop.
Resolution
1.859 Å
Binding residue
(original residue number in PDB)
R158 L159 K160 R161 R180 K184 H203 E386 K395
Binding residue
(residue number reindexed from 1)
R10 L11 K12 R13 R32 K36 H55 E238 K247
Enzymatic activity
Enzyme Commision number
2.7.7.86
: cyclic GMP-AMP synthase.
External links
PDB
RCSB:4o6a
,
PDBe:4o6a
,
PDBj:4o6a
PDBsum
4o6a
PubMed
24462292
UniProt
Q8C6L5
|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)
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