Structure of PDB 4nqa Chain B Binding Site BS03

Receptor Information
>4nqa Chain B (length=369) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRY
ACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQ
QQQESQSQSQSPVGPQGSSSQGSGEGEGVQLTAAQELMIQQLVAAQLQCN
KRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQV
PGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDD
FHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEP
GRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQV
FALRLQDKKLPPLLSEIWD
Ligand information
Receptor-Ligand Complex Structure
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PDB4nqa Structure of the retinoid X receptor alpha-liver X receptor beta (RXR alpha-LXR beta ) heterodimer on DNA.
Resolution3.102 Å
Binding residue
(original residue number in PDB)		K74 K75 E105 G106 R113 R138 R139 Q142 R145 K172 E177
Binding residue
(residue number reindexed from 1)		K1 K2 E32 G33 R40 R65 R66 Q69 R72 K99 E104
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0004879 nuclear receptor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006629 lipid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4nqa, PDBe:4nqa, PDBj:4nqa
PDBsum4nqa
PubMed24561505
UniProtP55055|NR1H2_HUMAN Oxysterols receptor LXR-beta (Gene Name=NR1H2)

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