Structure of PDB 4nnu Chain B Binding Site BS03
Receptor Information
>4nnu Chain B (length=192) Species:
9606
(Homo sapiens) [
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SVLASCPKKPVSSYLRFSKEQLPIFKAQNPDAKTTELIRRIAQRWRELPD
SKKKIYQDAYRAEWQVYKEEISRFKEQLTPSQIMSLEKEIMDKHLKRKAM
TKKKELTLLGKPKRPRSAYNVYVAERFQEAKGDSPQEKLKTVKENWKNLS
DSEKELYIQHAKEDETRYHNEMKSWEEQMIEVGRKDLLRRTI
Ligand information
>4nnu Chain F (length=22) [
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gccggtcccgataaccaactta
Receptor-Ligand Complex Structure
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PDB
4nnu
Distinct structural features of TFAM drive mitochondrial DNA packaging versus transcriptional activation.
Resolution
2.81 Å
Binding residue
(original residue number in PDB)
Y57 T78 I81 A85 W88 R89 Q100 K139 M143 K146 K147 K156 R157 R159 N163 P178
Binding residue
(residue number reindexed from 1)
Y14 T35 I38 A42 W45 R46 Q57 K96 M100 K103 K104 K113 R114 R116 N120 P135
Binding affinity
PDBbind-CN
: Kd=7.4nM
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:4nnu
,
PDBe:4nnu
,
PDBj:4nnu
PDBsum
4nnu
PubMed
24435062
UniProt
Q00059
|TFAM_HUMAN Transcription factor A, mitochondrial (Gene Name=TFAM)
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