Structure of PDB 4m83 Chain B Binding Site BS03

Receptor Information
>4m83 Chain B (length=394) Species: 1890 (Streptomyces antibioticus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TPAHIAMFSIAAHGHVNPSLEVIRELVARGHRVTYAIPPVFADKVAATGA
RPVLYHSTLPGPDADPEAWGSTLLDNVEPFLNDAIQALPQLADAYADDIP
DLVLHDITSYPARVLARRWGVPAVSLSPNLVAWKGYEEEVAEPMWREPRQ
TERGRAYYARFEAWLKENGITEHPDTFASHPPRSLVLIPKALQPHADRVD
EDVYTFVGACQGDRAEEGGWQRPAGAEKVVLVSLGSAFTKQPAFYRECVR
AFGNLPGWHLVLQIGRKVTPAELGELPDNVEVHDWVPQLAILRQADLFVT
HAGAGGSQEGLATATPMIAVPQAVDQFGNADMLQGLGVARKLATEEATAD
LLRETALALVDDPEVARRLRRIQAEMAQEGGTRRAADLIEAELP
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain4m83 Chain B Residue 503 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4m83 The crystal structure of two macrolide glycosyltransferases provides a blueprint for host cell antibiotic immunity.
Resolution1.698 Å
Binding residue
(original residue number in PDB)		R297 A299
Binding residue
(residue number reindexed from 1)		R293 A295
Annotation score4
Enzymatic activity
Enzyme Commision number 2.4.1.-
Gene Ontology
Molecular Function
GO:0008194 UDP-glycosyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0016758 hexosyltransferase activity
Biological Process
GO:0017000 antibiotic biosynthetic process
GO:0046677 response to antibiotic

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4m83, PDBe:4m83, PDBj:4m83
PDBsum4m83
PubMed
UniProtQ53685|OLED_STRAT Oleandomycin glycosyltransferase (Gene Name=oleD)

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