Structure of PDB 4kpy Chain B Binding Site BS03

Receptor Information
>4kpy Chain B (length=675) Species: 262724 (Thermus thermophilus HB27) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVARR
AGGVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDPKD
PGERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGAV
LDLWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRTW
ELLRLGEEDPKELPGGLSLLDYHASKGRLQGREGGRVAWVADPKPIPHLT
GLLVPVLTLEDLHEEELALSLPWEERRRRTREIASWIGRRLGLGTPEAVR
AQAYRLSIPKLMGRRAVSKPADALRVGFYRAQETALALLRLDGAQGWPEF
LRRALLRAFGASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQAVLVLT
PPMAWEDRNRLKALLLREGLPSQILNVPLREEERHRWENALLGLLAKAGL
QVVALSGAYPAELAVGFDAGGRESFRFGGAACAVGGDGGHLLWTLPEAQA
GERIPQEVVWDLLEETLWAFRRKAGRLPSRVLLLRDGRVPQDEFALALEA
LAREGIAYDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTVHRDF
RGTPRPLKLVHEAGDTPLEALAHQIFHLTRLYPASGFAFPRLPAPLHLAD
RLVKEVGRLGIRHLKEVDREKLFFV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4kpy Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage.
Resolution2.406 Å
Binding residue
(original residue number in PDB)		P44 R51 R81 R114 G547 R548 R574 K575 S576 K618
Binding residue
(residue number reindexed from 1)		P42 R49 R79 R112 G537 R538 R564 K565 S566 K608
Enzymatic activity
Enzyme Commision number 3.1.24.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004520 DNA endonuclease activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0044355 clearance of foreign intracellular DNA

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Molecular Function
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Biological Process
External links
PDB RCSB:4kpy, PDBe:4kpy, PDBj:4kpy
PDBsum4kpy
PubMed24374628
UniProtQ746M7|AGO_THET2 Protein argonaute (Gene Name=ago)

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