Structure of PDB 4k96 Chain B Binding Site BS03
Receptor Information
>4k96 Chain B (length=358) Species:
10090
(Mus musculus) [
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SPDKLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQL
NTGSYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFKPRGNP
LSHFLEGEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLL
IRNPEEISVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYL
VPKNAKDGNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKEC
LKLMKYLLEQLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSS
CFDKLLAFFLECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYER
NNGFPIFD
Ligand information
>4k96 Chain G (length=17) [
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aaattgccgaagacgaa
Receptor-Ligand Complex Structure
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PDB
4k96
Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.
Resolution
2.084 Å
Binding residue
(original residue number in PDB)
R158 L159 K160 R161 R180 E386 K395
Binding residue
(residue number reindexed from 1)
R13 L14 K15 R16 R35 E239 K248
Enzymatic activity
Enzyme Commision number
2.7.7.86
: cyclic GMP-AMP synthase.
External links
PDB
RCSB:4k96
,
PDBe:4k96
,
PDBj:4k96
PDBsum
4k96
PubMed
23647843
UniProt
Q8C6L5
|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)
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