Structure of PDB 4g0u Chain B Binding Site BS03

Receptor Information

>4g0u Chain B (length=668) Species: 9606 (Homo sapiens)

GIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPL
RGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDAESLKTLRYGKI
MIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITAKEAKEYFADM
ERHRILFRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLTKHL
TYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVK
VAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTR
LHGGKDAASPRYIFTMLSTLARLLFPAVDDNLLKFLYDDNQRVEPEWYIP
IIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLDGLDPHPMLPNYK
NFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPM
LNGTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQT
TLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGA
ESTKLNNQARFILEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEA
QGPDFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSDLWKED
LAAFVEELDKVESQERED

Ligand information

>4g0u Chain F (length=12)

tgcagctcggct

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4g0u On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): G453 D479 S480 R503 Q778
• Binding residue (residue number reindexed from 1): G1 D27 S28 R51 Q269

Enzymatic activity

• Enzyme Commision number: 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
• GO:0005524 ATP binding

Biological Process

• GO:0006259 DNA metabolic process
• GO:0006265 DNA topological change

External links

• PDB: RCSB:4g0u, PDBe:4g0u, PDBj:4g0u
• PDBsum: 4g0u
• PubMed: 24038465
• UniProt: Q02880|TOP2B_HUMAN DNA topoisomerase 2-beta (Gene Name=TOP2B)