Structure of PDB 4aqa Chain B Binding Site BS03

Receptor Information

>4aqa Chain B (length=237) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MQYDDDWQYEDCKLARGGPPATIVAIDEESRNGTILVDNMLIKGTAGGPD
PTIELSLKDNVDYWVLLDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC
VNKKVGTVIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGF
SGDNGATDIDDGPNGQIEYVIQYNPEDPTSNDTFEIPLMLTGNVVLRKRL
NYEDKTRYYVIIQANDRAQNLNERRTTTTTLTVDLEH

Ligand information

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

4aqa Chain B Residue 1239 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4aqa Structure of a Force-Conveying Cadherin Bond Essential for Inner-Ear Mechanotransduction
Resolution	1.96 Å
Binding residue (original residue number in PDB)	N120 N122 D157 D159 N163 D215
Binding residue (residue number reindexed from 1)	N121 N123 D158 D160 N164 D216
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005509	calcium ion binding

	Biological Process
GO:0007155	cell adhesion
GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
GO:0007605	sensory perception of sound
GO:0048839	inner ear development

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0032420	stereocilium

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:4aqa, PDBe:4aqa, PDBj:4aqa
PDBsum	4aqa
PubMed	23135401
UniProt	Q99PJ1\|PCD15_MOUSE Protocadherin-15 (Gene Name=Pcdh15)

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