Structure of PDB 4aq8 Chain B Binding Site BS03

Receptor Information
>4aq8 Chain B (length=208) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLARDMDNDPLVFGVSGE
EASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNIQV
GDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQ
PPSPFFAIDSARGIVTVIQELDYEVTQAYQLTVNATDQDKTRPLSTLANL
AIIITDLE
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain4aq8 Chain B Residue 1211 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4aq8 Structure of a Force-Conveying Cadherin Bond Essential for Inner-Ear Mechanotransduction
Resolution2.63 Å
Binding residue
(original residue number in PDB)		N104 N106 D136 D138 G142 D187
Binding residue
(residue number reindexed from 1)		N104 N106 D136 D138 G142 D187
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Biological Process
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
GO:0098609 cell-cell adhesion
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4aq8, PDBe:4aq8, PDBj:4aq8
PDBsum4aq8
PubMed23135401
UniProtQ99PF4|CAD23_MOUSE Cadherin-23 (Gene Name=Cdh23)

[Back to BioLiP]