Structure of PDB 4acb Chain B Binding Site BS03

Receptor Information
>4acb Chain B (length=456) Species: 39152 (Methanococcus maripaludis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDFKNINLGIFGHIDHGKTTLSKVLTEIAKRGITIDIGFSAFKLENYRIT
LVDAPGHADLIRAVVSAADIIDLALIVVDAKEGPKTQTGEHMLILDHFNI
PIIVVITKSDNAGTEEIKRTEMIMKSILQSTHNLKNSSIIPISAKTGFGV
DELKNLIITTLNNAEIIRNTESYFKMPLDHAFPIKGAGTVVTGTINKGIV
KVGDELKVLPINMSTKVRSIQYFKESVMEAKAGDRVGMAIQGVDAKQIYR
GCILTSKDTKLQTVDKIVAKIKISDIFKYNLTPKMKVHLNVGMLIVPAVA
VPFKKVTFGKTEENIILNEVISGNECYCAFELEEKVLAEVGDRVLITRLD
LPPTTLRICGHGLIEEFKPIKDLNIKKEVLREGKVKIDKGRTVIDGLAQS
KVAAEKLIGEEISIEGKDIVGKIKGTFGTKGLLTAEFSGNVENRDKVILN
RLRRWG
Ligand information
Ligand ID5GP
InChIInChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
InChIKeyRQFCJASXJCIDSX-UUOKFMHZSA-N
SMILES
SoftwareSMILES
CACTVS 3.341NC1=Nc2n(cnc2C(=O)N1)[C@@H]3O[C@H](CO[P](O)(O)=O)[C@@H](O)[C@H]3O
CACTVS 3.341NC1=Nc2n(cnc2C(=O)N1)[CH]3O[CH](CO[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=C1c2ncn(c2N=C(N)N1)C3OC(C(O)C3O)COP(=O)(O)O
OpenEye OEToolkits 1.5.0c1nc2c(n1C3C(C(C(O3)COP(=O)(O)O)O)O)N=C(NC2=O)N
OpenEye OEToolkits 1.5.0c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O)O)O)O)N=C(NC2=O)N
FormulaC10 H14 N5 O8 P
NameGUANOSINE-5'-MONOPHOSPHATE
ChEMBLCHEMBL283807
DrugBankDB01972
ZINCZINC000002159505
PDB chain4acb Chain B Residue 1474 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4acb Selenocysteine tRNA-Specific Elongation Factor Selb is a Structural Chimaera of Elongation and Initiation Factors.
Resolution3.34 Å
Binding residue
(original residue number in PDB)		P96 K97 T98 M104 I139 T143 I288
Binding residue
(residue number reindexed from 1)		P84 K85 T86 M92 I127 T131 I276
Annotation score3
Enzymatic activity
Catalytic site (original residue number in PDB) D15 K18 T19 T46 H69
Catalytic site (residue number reindexed from 1) D15 K18 T19 T34 H57
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0046872 metal ion binding
Biological Process
GO:0001514 selenocysteine incorporation
GO:0006414 translational elongation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4acb, PDBe:4acb, PDBj:4acb
PDBsum4acb
PubMed15616587
UniProtQ8J307

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