Structure of PDB 3wqz Chain B Binding Site BS03

Receptor Information
>3wqz Chain B (length=904) Species: 224325 (Archaeoglobus fulgidus DSM 4304) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MTLDEEYLDITFLTENGFVRKRCPKCGKHFWTADPEREICGDPPCESYSF
IGNPVFKKPFELDEMREYYLNFFERRGHGRIERYPVVARWRTDIYLTIAS
IADFQPFVTSGVAPPPANPLTISQPCIRLDDLDSVGRTGRHLTLFEMMAH
HAFNYPGKEIYWKNETVAYCTELLNELGVKKEDIVYKEEPWAGGGNAGPC
LEAIVGGLEVATLVFMNLEEHPEGDIEIKGARYRKMDNYIVDTGYGLERF
VWASKGTPTVYDAIFPEVVDTIIDNSNVSFNREDERVRRIVAESSKLAGI
MGELRGERLNQLRKSVADTVGVSVEELEGIVVPLEKVYSLADHTRCILFM
LGDGLVPSNAGAGYLARLMIRRSLRLAEELELGLDLYDLVEMHKKILGFE
FDVPLSTVQEILELEKERYRTTVSKGTRLVERLVERKKKLEKDDLIELYD
SHGIPVELAVGIAAEKGAEVEMPKDIYAELAKRHSKAEKVQEKKITLQNE
YPATEKLYYDDPTLLEFEAEVIGVEGDFVILNRSAFYPESGGQDNDVGYL
IANGGKFEVVDVLEADGVVLHVVKGAKPEVGTKVKGVIDSDVRWRHMRHH
SATHVLLYSLQKVLGNHVWQAGARKEFSKARLDVTHFRRPSEEEIKEIEM
LANREILANKPIKWEWMDRIEAERKFGFRLYQGGVPPGRKIRVVQVGDDV
QACGGTHCRSTGEIGMLKILKVESIQDGVIRFEFAAGEAAIEAVEEMERL
LREASSILRVEPAKLPKTVERFFEEWKDQRKEIERLKSVIADLWADILME
RAEEFDSMKVVAEVVDADMQALQKLAERLAEKGAVGCLMAKGEGKVFVVT
FSGQKYDARELLREIGRVAKGSGGGRKDVAQGAVQQLLDREEMLDVIFRF
LSEH
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain3wqz Chain B Residue 1002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3wqz The selective tRNA aminoacylation mechanism based on a single G.U pair
Resolution3.489 Å
Binding residue
(original residue number in PDB)		H600 H604
Binding residue
(residue number reindexed from 1)		H600 H604
Annotation score1
Enzymatic activity
Enzyme Commision number 6.1.1.7: alanine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0000166 nucleotide binding
GO:0002161 aminoacyl-tRNA editing activity
GO:0003676 nucleic acid binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004813 alanine-tRNA ligase activity
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0006419 alanyl-tRNA aminoacylation
GO:0043039 tRNA aminoacylation
GO:0106074 aminoacyl-tRNA metabolism involved in translational fidelity
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3wqz, PDBe:3wqz, PDBj:3wqz
PDBsum3wqz
PubMed24919148
UniProtO28029|SYA_ARCFU Alanine--tRNA ligase (Gene Name=alaS)

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