Structure of PDB 3us0 Chain B Binding Site BS03

Receptor Information
>3us0 Chain B (length=193) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MASPSNTDYPGPHSFDVSFQSATWTYSTELKKLYCQIAKTCPIQIKVMTP
PPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVE
GNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNR
RPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRK
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain3us0 Chain B Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB3us0 Pliable DNA Conformation of Response Elements Bound to Transcription Factor p63.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		C205 H208 C269 C273
Binding residue
(residue number reindexed from 1)		C76 H79 C140 C144
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006915 apoptotic process
Cellular Component
GO:0005634 nucleus

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3us0, PDBe:3us0, PDBj:3us0
PDBsum3us0
PubMed22247550
UniProtQ9H3D4|P63_HUMAN Tumor protein 63 (Gene Name=TP63)

[Back to BioLiP]