Structure of PDB 3gbr Chain B Binding Site BS03

Receptor Information

>3gbr Chain B (length=343) Species: 2287 (Saccharolobus solfataricus)

NINEILKKLINKSDLEINEAEELAKAIIRGEVPEILVSAILVALRMKGES
KNEIVGFARAMRELAIKIDVPNAIDTAGTGGGGLGTVNVSTASAILLSLV
NPVAKHGNRAVSGKSGSADVLEALGYNIIVPPERAKELVNKTNFVFLSAQ
YYHPAMKNVANVRKTLGIRTIFNILGPLTNPANAKYQLMGVFSKDHLDLL
SKSAYELDFNKIILVYGEPGIDEVSPIGNTFMKIVSKRGIEEVKLNVTDF
GISPIPIEKLIVNSAEDSAIKIVRAFLGKDEHVAEFIKINTAVALFALDR
VGDFREGYEYADHLIEKSLDKLNEIISMNGDVTKLKTIVVKSS

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 3gbr Chain B Residue 504

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3gbr Activation of anthranilate phosphoribosyltransferase from Sulfolobus solfataricus by removal of magnesium inhibition and acceleration of product release
• Resolution: 2.25 Å
• Binding residue (original residue number in PDB): D223 E224
• Binding residue (residue number reindexed from 1): D222 E223
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.4.2.18: anthranilate phosphoribosyltransferase.

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0004048 anthranilate phosphoribosyltransferase activity
• GO:0016757 glycosyltransferase activity
• GO:0016763 pentosyltransferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0000162 tryptophan biosynthetic process

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:3gbr, PDBe:3gbr, PDBj:3gbr
• PDBsum: 3gbr
• PubMed: 19385665
• UniProt: P50384|TRPD_SACS2 Anthranilate phosphoribosyltransferase (Gene Name=trpD)