Structure of PDB 3e0d Chain B Binding Site BS03

Receptor Information
>3e0d Chain B (length=1148) Species: 271 (Thermus aquaticus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LKFAHLHQHTQFSLLNGAAKLQDLLKWVKETTPEDPALAMTDHGNLFGAV
EFYKKATAMGVKPIIGYEAYVAAESRFDRKRGGYFHLTLLAKDFTGYQNL
VRLASRAYLEGFYEKPRIDREILREHAQGLIALSGCLGAEIPQFILQDRL
DLAEARLNEDLSIFGDRFFIEIQNHGLPEQKKVNQVLKEFARKYGLGMVA
TNNGHYVRKEDARAHEVLLAIQSKTTLDDPERWRFPCDEFYVKTPEEMRA
MLPEAEWGDEPFDNTVEIARMCDVDLPIGDKMVYRIPRFPLGRTEAQYLR
ELTFLGLLRRYPDRITEAFYREVLRLLDERALAEALARVEEKAWEELRKR
EWTAEAILHRALYELSVIERMGFPGYFLIVQDYINWARGHGVSVGPGRGS
AAGSLVAYAVGITNIDPLRFGLLFERFLNPERVSMPDIDTDFSDRERDRV
IQYVRERYGEDKVAQIGTFGSLASKAALKDVARVYGIPHKKAEELAKLIP
VQFGKPKPLQEAFEAEPELRAEMEKDERIRQVIEVAMRLEGLNRHASVHA
AGVVIAAEPLTDLVPLMRDQEGRPVTQYDMGAVEALGLLKMDFLGLRTLT
FLDEARRIVKESKGVELDYDRLPLDDPKTFELLSRGETKGVFQLESGGMT
ATVRGLKPRRLEDIIALVSLYRPGPMEHIPTYIRRHHGQEPVSYAEFPHA
EKYLRPILDETYGIPVYQEQIMQIASQVAGYSLGEADLLRRAMGKKRVEE
MQKHRERFVRGAKERGVPEEEANRLFDMLEAFANYGFNKSHAAAYSLLSY
QTAYVKAHYPVEFMAALLSVERHDSDKVAEYIRDARALGIPVLPPDVNRS
GFDFKVVGEEILFGLSAVKNVGEMAARAILEERERGGPFKSLGDFLKRLP
EQVVNKRALESLVKAGALDAFGDRARLLASLEPLLRWAAETRERGRSGLV
GLFAEVEEPPLVEASPLDEITMLRYEKEALGIYVSGHPVLRYPGLREVAS
CTIEELSEFVRELPGKPKVLLSGMVEEVRFTLSDETGALEVVKEDIPLLV
LAEVERVLAQAVWTLEEVLEAPKALEVEVDHALLDEKGARLKSLLDEHPG
SLPVYLRVLGPFGEALFALREVRVGEEALGLLEAEGYRAYLVPDREVF
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain3e0d Chain B Residue 1221 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3e0d Insights into the Replisome from the Structure of a Ternary Complex of the DNA Polymerase III alpha-Subunit.
Resolution4.6 Å
Binding residue
(original residue number in PDB)		D463 D465
Binding residue
(residue number reindexed from 1)		D437 D439
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003887 DNA-directed DNA polymerase activity
GO:0008408 3'-5' exonuclease activity
Biological Process
GO:0006260 DNA replication
GO:0071897 DNA biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3e0d, PDBe:3e0d, PDBj:3e0d
PDBsum3e0d
PubMed18691598
UniProtQ9XDH5|DPO3A_THEAQ DNA polymerase III subunit alpha (Gene Name=dnaE)

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