Structure of PDB 2zof Chain B Binding Site BS03

Receptor Information
>2zof Chain B (length=478) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SPNSMSALKAVFQYIDENQDRYVKKLAEWVAIQSVSAWPEKRGEIRRMME
VAAADVQRLGGSVELVDIGKQKLPDGSEIPLPPILLGKLGSDPQKKTVCI
YGHLDVQPAALEDGWDSEPFTLVEREGKLYGRGSTDDKGPVAGWMNALEA
YQKTGQEIPVNLRFCLEGMEESGSEGLDELIFAQKDKFFKDVDYVCISDN
YWLGKNKPCITYGLRGICYFFIEVECSDKDLHSGVYGGSVHEAMTDLISL
MGCLVDKKGKILIPGINDAVAPVTDEEHALYDHIDFDMEEFAKDVGAETL
LHSCKKDILMHRWRYPSLSLHGIEGAFSGSGAKTVIPRKVVGKFSIRLVP
DMIPEVVSEQVSSYLSKKFAELQSPNKFKVYMGHGGKPWVSDFNHPHYQA
GRRALKTVFGVEPDLTREGGSIPVTLTFQEATGKNVMLLPVGSADDGAHS
QNEKLNRLNYIEGTKMLAAYLYEVSQLK
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain2zof Chain B Residue 3002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2zof Structural basis for substrate recognition and hydrolysis by mouse carnosinase CN2.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		H99 D132 D195
Binding residue
(residue number reindexed from 1)		H103 D136 D199
Annotation score1
Enzymatic activity
Enzyme Commision number 3.4.13.18: cytosol non-specific dipeptidase.
Gene Ontology
Molecular Function
GO:0004180 carboxypeptidase activity
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0016787 hydrolase activity
GO:0016805 dipeptidase activity
GO:0046872 metal ion binding
GO:0070573 metallodipeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2zof, PDBe:2zof, PDBj:2zof
PDBsum2zof
PubMed18550540
UniProtQ9D1A2|CNDP2_MOUSE Cytosolic non-specific dipeptidase (Gene Name=Cndp2)

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