Structure of PDB 2z2p Chain B Binding Site BS03

Receptor Information

>2z2p Chain B (length=293) Species: 1280 (Staphylococcus aureus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

EFKLQELNLTNQDTGPYGITVSDKGKVWITQHKANMISCINLDGKITEYE
LPNKGAKVMCLTISSDGEVWFTENAANKIGRITKKGIIKEYTLPNPDSAP
YGITEGPNGDIWFTEMNGNRIGRITDDGKIREYELPNKGSYPSFITLGSD
NALWFTENQNNAIGRITESGDITEFKIPTPASGPVGITKGNDDALWFVEI
IGNKIGRITTSGEITEFKIPTPNARPHAITAGAGIDLWFTEWGANKIGRL
TSNNIIEEYPIQIKSAEPAGICFDGETIWFAMECDKIGKLTLI

Ligand information

Ligand ID

InChI

InChI=1S/Mg/q+2

InChIKey

JLVVSXFLKOJNIY-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mg+2]
CACTVS 3.341	[Mg++]

Formula

Name

MAGNESIUM ION

PDB chain

2z2p Chain B Residue 1004 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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PDB	2z2p Structural Basis for Streptogramin B Resistance in Staphylococcus Aureus by Virginiamycin B Lyase
Resolution	2.8 Å
Binding residue (original residue number in PDB)	D67 E69 D127
Binding residue (residue number reindexed from 1)	D66 E68 D126
Annotation score	4

Enzymatic activity

Enzyme Commision number

4.2.99.-

Gene Ontology

	Molecular Function
GO:0000287	magnesium ion binding
GO:0016829	lyase activity
GO:0016835	carbon-oxygen lyase activity
GO:0046872	metal ion binding

	Biological Process
GO:0017001	antibiotic catabolic process
GO:0046677	response to antibiotic

	Cellular Component
GO:0030288	outer membrane-bounded periplasmic space

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External links

PDB	RCSB:2z2p, PDBe:2z2p, PDBj:2z2p
PDBsum	2z2p
PubMed	17563376
UniProt	P17978\|VGB_STAAU Virginiamycin B lyase (Gene Name=vgb)

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