Structure of PDB 2yz5 Chain B Binding Site BS03

Receptor Information
>2yz5 Chain B (length=265) Species: 274 (Thermus thermophilus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MVDSHVHTPLCGHAEGHPEAYLEEARAKGLKGVVFTDHSPMPPWYDPESR
MRLEALPFYLLALERVRERAQDLYVGIGLEADFHPGTEGFLAQLLRRYPF
DYVIGSVHYLGAWPLDHPDHQEEYAWRDLKEVFRAYFQEVEKAARSGLFH
AIGHLDLPKKFGHRLPEEALLELAEPALRAVAEAGLFLDVNTAGLRRPAK
EVYPAPALLRRARELGIGLVLGSDAHRPEEVGFAFPEVQALLAGLGFREA
YYFVEGSPVAYPLSR
Ligand information
Ligand IDFE
InChIInChI=1S/Fe/q+3
InChIKeyVTLYFUHAOXGGBS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Fe+3]
FormulaFe
NameFE (III) ION
ChEMBL
DrugBankDB13949
ZINC
PDB chain2yz5 Chain B Residue 1503 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2yz5 Crystal Structure of Monofunctional Histidinol Phosphate Phosphatase from Thermus thermophilus HB8.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		H5 H7 E80 D224
Binding residue
(residue number reindexed from 1)		H5 H7 E80 D224
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.3.15: histidinol-phosphatase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004401 histidinol-phosphatase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0000105 L-histidine biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2yz5, PDBe:2yz5, PDBj:2yz5
PDBsum2yz5
PubMed17929834
UniProtQ5SLG2

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