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Receptor Information

>2vl8 Chain B (length=533) Species: 1505 (Paraclostridium sordellii) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

LVNKAQLQKMAYVKFRIQEDEYVAILNALEEYHNMSESSVVEKYLKLKDI
NNLTDNYLNTYKKSGRNKALKKFKEYLTMEVLELKNNSLTPVEKNLHFIW
IGGQINDTAINYINQWKDVNSDYTVKVFYDSNAFLINTLKKTIVESATNN
TLESFRENLNDPEFDYNKFYRKRMEIIYDKQKHFIDYYKSQIEENPEFII
DNIIKTYLSNEYSKDLEALNKYIEESLNKITANNGNDIRNLEKFADEDLV
RLYNQELVERWNLAAASDILRISMLKEDGGVYLDVDMLPGIQPDLFKSIN
KPDSITNTSWEMIKLEAIMKYKEYIPGYTSKNFDMLDEEVQRSFESALSS
KSDKSEIFLPLDDIKVSPLEVKIAFANNSVINQALISLKDSYCSDLVINQ
IKNRYKILNDNLNPSINEGTDFNTTMKIFSDKLASISNEDNMMFMIKITN
YLKVGFAPDVRSTINLSGPGVYTGAYQDLLMFKDNSTNIHLLEPELRNFE
FPKTKISQLTEQEITSLARAKSQFEEYKKGYFE

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

2vl8 Chain B Residue 1545 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	2vl8 Inhibition of the Glucosyltransferase Activity of Clostridial Rho/Ras-Glucosylating Toxins by Castanospermine.
Resolution	2.31 Å
Binding residue (original residue number in PDB)	D288 E515 S518
Binding residue (residue number reindexed from 1)	D286 E513 S516
Annotation score	1

Enzyme Commision number

2.4.1.-
3.4.22.-

	Molecular Function
GO:0016757	glycosyltransferase activity

PDB	RCSB:2vl8, PDBe:2vl8, PDBj:2vl8
PDBsum	2vl8
PubMed	18505687
UniProt	Q46342\|TCSL1_PARSO Cytotoxin-L (Gene Name=tcsL)

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Structure of PDB 2vl8 Chain B Binding Site BS03