Structure of PDB 2r8k Chain B Binding Site BS03

Receptor Information

>2r8k Chain B (length=511) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GRMSKFTWKELIQLGSPSKAYESSLACIAHIDMNAFFAQVEQMRCGLSKE
DPVVCVQWNSIIAVSYAARKYGISRMDTIQEALKKCSNLIPIHTAVFKKG
EDFWQYHDGCGSWVQDPAKQISVEDHKVSLEPYRRESRKALKIFKSACDL
VERASIDEVFLDLGRICFNMLMFDNEYELTGDLKLKDALSNIREAFIGGN
YDINSHLPLIPEKIKSLKFEGDVFNPEGRDLITDWDDVILALGSQVCKGI
RDSIKDILGYTTSCGLSSTKNVCKLASNYKKPDAQTIVKNDCLLDFLDCG
KFEITSFWTLGGVLGKELIDVLDLPHENSIKHIRETWPDNAGQLKEFLDA
KVKQSDYDRSTSNIDPLKTADLAEKLFKLSRGRYGLPLSSRPVVKSMMSN
KNLRGKSCNSIVDCISWLEVFCAELTSRIQDLEQEYNKIVIPRTVSISLK
TKSYEVYRKSGPVAYKGINFQSHELLKVGIKFVTDLDIKGKNKSYYPLTK
LSMTITNFDII

Ligand information

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

2r8k Chain B Residue 3001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	2r8k Bypass of DNA lesions generated during anticancer treatment with cisplatin by DNA polymerase eta
Resolution	3.3 Å
Binding residue (original residue number in PDB)	D30 D155 E156
Binding residue (residue number reindexed from 1)	D32 D157 E158
Annotation score	1

Enzymatic activity

Enzyme Commision number

2.7.7.7: DNA-directed DNA polymerase.

Gene Ontology

	Molecular Function
GO:0003684	damaged DNA binding

	Biological Process
GO:0006281	DNA repair

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Molecular Function

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Biological Process

External links

PDB	RCSB:2r8k, PDBe:2r8k, PDBj:2r8k
PDBsum	2r8k
PubMed	17991862
UniProt	Q04049\|POLH_YEAST DNA polymerase eta (Gene Name=RAD30)

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