Structure of PDB 2qv6 Chain B Binding Site BS03

Receptor Information
>2qv6 Chain B (length=250) Species: 2190 (Methanocaldococcus jannaschii) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MIQITVIQIDNYGPWTVTPNPRRESDLQALQSRLYADLNLMFGAHKGLVF
YTRFDNLIAITNGIDLITHKRIQESIRNRYPFTVSMVIASAETPYEAQKL
ATETLQEYGSAQDENRKEVLDVANELVVDGYVQIAHIDINNITGTLTDIV
SAYDTYLNVNKVKLALMEELLKYNALLFFIGGDNFMAPSNGMSEEDFLDI
FNRINKKYKIELKAGIGIGRTAEDASNLADIGLEKIRGKLVDKNVCTLKQ
Ligand information
Ligand IDK
InChIInChI=1S/K/q+1
InChIKeyNPYPAHLBTDXSSS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[K+]
FormulaK
NamePOTASSIUM ION
ChEMBLCHEMBL1233793
DrugBankDB01345
ZINC
PDB chain2qv6 Chain D Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2qv6 A New Use for a Familiar Fold: The X-ray Crystal Structure of GTP-Bound GTP Cyclohydrolase III from Methanocaldococcus jannaschii Reveals a Two Metal Ion Catalytic Mechanism
Resolution2.0 Å
Binding residue
(original residue number in PDB)		R22 E24
Binding residue
(residue number reindexed from 1)		R22 E24
Annotation score1
Enzymatic activity
Enzyme Commision number 3.5.4.29: GTP cyclohydrolase IIa.
Gene Ontology
Molecular Function
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
GO:0043740 GTP cyclohydrolase IIa activity
Biological Process
GO:0009058 biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:2qv6, PDBe:2qv6, PDBj:2qv6
PDBsum2qv6
PubMed18052207
UniProtQ57609|GCH3_METJA GTP cyclohydrolase III (Gene Name=gch3)

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