Structure of PDB 2pok Chain B Binding Site BS03

Receptor Information

>2pok Chain B (length=456) Species: 170187 (Streptococcus pneumoniae TIGR4) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

VFPSEQEQIEKFEKDHVAQHYFEVLRTLISKKSVFAQQVGLKEVANYLGE
IFKRVGAEVEIDESYTAPFVMAHFKSSRPDAKTLIFYNHYDTVPADGDQV
WTEDPFTLSVRNGFMYGRGVDDDKGHITARLSALRKYMQHHDDLPVNISF
IMEGAEESASTDLDKYLEKHADKLRGADLLVWEQGTKNALEQLEISGGNK
GIVTFDAKVKSADVDIHSSYGGVVESAPWYLLQALQSLRAADGRILVEGL
YEEVQEPNEREMALLETYGQRNPEEVSRIYGLELPLLQEERMAFLKRFFF
DPALNIEGIQSGYQGQGVKTILPAEASAKLEVRLVPGLEPHDVLEKIRKQ
LDKNGFDKVELYYTLGEMSYRSDMSAPAILNVIELAKKFYPQGVSVLPTT
AGTGPMHTVFDALEVPMVAFGLGNANSRDHGGDENVRIADYYTHIELVEE
LIRSYE

Ligand information

Ligand ID

InChI

InChI=1S/Mn/q+2

InChIKey

WAEMQWOKJMHJLA-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mn+2]
CACTVS 3.341	[Mn++]

Formula

Name

MANGANESE (II) ION

PDB chain

2pok Chain B Residue 460 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	2pok Crystal structure of a M20 family metallo peptidase from Streptococcus pneumoniae.
Resolution	1.9 Å
Binding residue (original residue number in PDB)	H90 D123 E157 E184 Q185
Binding residue (residue number reindexed from 1)	H89 D122 E156 E183 Q184
Annotation score	1

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0009014	succinyl-diaminopimelate desuccinylase activity
GO:0016787	hydrolase activity
GO:0046872	metal ion binding

	Biological Process
GO:0009089	lysine biosynthetic process via diaminopimelate

	Cellular Component
GO:0005829	cytosol

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Molecular Function

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Cellular Component

External links

PDB	RCSB:2pok, PDBe:2pok, PDBj:2pok
PDBsum	2pok
PubMed
UniProt	A0A0H2UN21

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