Structure of PDB 2p1q Chain B Binding Site BS03

Receptor Information
>2p1q Chain B (length=568) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FPEEVLEHVFSFIQLDKDRNSVSLVCKSWYEIERWCRRKVFIGNCYAVSP
ATVIRRFPKVRSVELKGKPHFADFNLVPDGWGGYVYPWIEAMSSSYTWLE
EIRLKRMVVTDDCLELIAKSFKNFKVLVLSSCEGFSTDGLAAIAATCRNL
KELDLRESDVDDVSGHWLSHFPDTYTSLVSLNISCLASEVSFSALERLVT
RCPNLKSLKLNRAVPLEKLATLLQRAPQLEELGTGGYTAEVRPDVYSGLS
VALSGCKELRCLSGFWDAVPAYLPAVYSVCSRLTTLNLSYATVQSYDLVK
LLCQCPKLQRLWVLDYIEDAGLEVLASTCKDLRELRVFPSEPFVMEPNVA
LTEQGLVSVSMGCPKLESVLYFCRQMTNAALITIARNRPNMTRFRLCIIE
PKAPDYLTLEPLDIGFGAIVEHCKDLRRLSLSGLLTDKVFEYIGTYAKKM
EMLSVAFAGDSDLGMHHVLSGCDSLRKLEIRDCPFGDKALLANASKLETM
RSLWMSSCSVSFGACKLLGQKMPKLNVEVIDERGAPDSRPESCPVERVFI
YRTVAGPRFDMPGFVWNM
Ligand information
Ligand IDIAC
InChIInChI=1S/C10H9NO2/c12-10(13)5-7-6-11-9-4-2-1-3-8(7)9/h1-4,6,11H,5H2,(H,12,13)
InChIKeySEOVTRFCIGRIMH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6c1ccc2c(c1)c(c[nH]2)CC(=O)O
ACDLabs 12.01O=C(O)Cc2c1ccccc1nc2
CACTVS 3.370OC(=O)Cc1c[nH]c2ccccc12
FormulaC10 H9 N O2
Name1H-INDOL-3-YLACETIC ACID;
INDOLE ACETIC ACID
ChEMBLCHEMBL82411
DrugBankDB07950
ZINCZINC000000083860
PDB chain2p1q Chain B Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB2p1q Mechanism of auxin perception by the TIR1 ubiquitin ligase.
Resolution1.91 Å
Binding residue
(original residue number in PDB)		F79 R403 L404 S438 L439 S462
Binding residue
(residue number reindexed from 1)		F71 R395 L396 S430 L431 S454
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000822 inositol hexakisphosphate binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0010011 auxin binding
GO:0038198 auxin receptor activity
Biological Process
GO:0006952 defense response
GO:0009733 response to auxin
GO:0009734 auxin-activated signaling pathway
GO:0009873 ethylene-activated signaling pathway
GO:0010152 pollen maturation
GO:0010311 lateral root formation
GO:0016036 cellular response to phosphate starvation
GO:0016567 protein ubiquitination
GO:0048443 stamen development
Cellular Component
GO:0005634 nucleus
GO:0019005 SCF ubiquitin ligase complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2p1q, PDBe:2p1q, PDBj:2p1q
PDBsum2p1q
PubMed17410169
UniProtQ570C0|TIR1_ARATH Protein TRANSPORT INHIBITOR RESPONSE 1 (Gene Name=TIR1)

[Back to BioLiP]