Structure of PDB 2igq Chain B Binding Site BS03

Receptor Information

>2igq Chain B (length=254) Species: 9606 (Homo sapiens)

ERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNI
THLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECN
HACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYV
GELISDSEADVREEDSYLFDLDEVYCIDARFYGNVSRFINHHCEPNLVPV
RVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKLFSCRCGSPK
CRHS

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 2igq Chain B Residue 503

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2igq Structural biology of human H3K9 methyltransferases
• Resolution: 2.0 Å
• Binding residue (original residue number in PDB): C1031 C1033 C1037 C1042
• Binding residue (residue number reindexed from 1): C56 C58 C62 C67
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): Y1124 Y1211
• Catalytic site (residue number reindexed from 1): Y149 Y232
• Enzyme Commision number: 2.1.1.-
  2.1.1.367: [histone H3]-lysine(9) N-methyltransferase.

Gene Ontology

Molecular Function

• GO:0002039 p53 binding
• GO:0008270 zinc ion binding
• GO:0016279 protein-lysine N-methyltransferase activity
• GO:0042054 histone methyltransferase activity
• GO:0046974 histone H3K9 methyltransferase activity

Cellular Component

• GO:0005634 nucleus

External links

• PDB: RCSB:2igq, PDBe:2igq, PDBj:2igq
• PDBsum: 2igq
• PubMed: 20084102
• UniProt: Q9H9B1|EHMT1_HUMAN Histone-lysine N-methyltransferase EHMT1 (Gene Name=EHMT1)