Structure of PDB 2hp1 Chain B Binding Site BS03

Receptor Information
>2hp1 Chain B (length=398) Species: 269084 (Synechococcus elongatus PCC 6301) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FKTIKSDEIFAAAQKLMPGGVSSPVRAFKSVGGQPIVFDRVKDAYAWDVD
GNRYIDYVGTWGPAICGHAHPEVIEALKVAMEKGTSFGAPCALENVLAEM
VNDAVPSIEMVRFVNSGTEACMAVLRIMRAYTGRDKIIKFEGCYHGHNTL
TTPYNDLEAVKALFAENPGEIAGVILEPIVGNSGFIVPDAGFLEGLREIT
LEHDALLVFDEVMTGFRIAYGGVQEKFGVTPDLTTLGKIIGGGLPVGAYG
GKREIMQLVAPAGPMYQAGTLSGNPLAMTAGIKTLELLRQPGTYEYLDQI
TKRLSDGLLAIAQETGHAACGGQVSGMFGFFFTEGPVHNYEDAKKSDLQK
FSRFHRGMLEQGIYLAPSQFEAGFTSLAHTEEDIDATLAAARTVMSAL
Ligand information
Ligand IDHOZ
InChIInChI=1S/C5H12N2O2/c6-3-4(7)1-2-5(8)9/h4H,1-3,6-7H2,(H,8,9)/t4-/m0/s1
InChIKeyPQGAAJQIFBEYSA-BYPYZUCNSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(CC(=O)O)[C@@H](CN)N
OpenEye OEToolkits 1.5.0C(CC(=O)O)C(CN)N
CACTVS 3.341NC[CH](N)CCC(O)=O
CACTVS 3.341NC[C@@H](N)CCC(O)=O
ACDLabs 10.04O=C(O)CCC(N)CN
FormulaC5 H12 N2 O2
Name(4S)-4,5-DIAMINOPENTANOIC ACID
ChEMBL
DrugBank
ZINCZINC000038792051
PDB chain2hp1 Chain B Residue 2 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2hp1 Intersubunit signaling in glutamate-1-semialdehyde-aminomutase.
Resolution2.08 Å
Binding residue
(original residue number in PDB)		S2029 V2031 R2032 W2067 Y2150
Binding residue
(residue number reindexed from 1)		S23 V25 R26 W61 Y144
Annotation score2
Enzymatic activity
Catalytic site (original residue number in PDB) V2027 Y2150 E2212 D2245 M2248 K2273 A2407
Catalytic site (residue number reindexed from 1) V21 Y144 E177 D210 M213 K238 A372
Enzyme Commision number 5.4.3.8: glutamate-1-semialdehyde 2,1-aminomutase.
Gene Ontology
Molecular Function
GO:0008483 transaminase activity
GO:0016853 isomerase activity
GO:0030170 pyridoxal phosphate binding
GO:0042286 glutamate-1-semialdehyde 2,1-aminomutase activity
Biological Process
GO:0006782 protoporphyrinogen IX biosynthetic process
GO:0015995 chlorophyll biosynthetic process
GO:0033014 tetrapyrrole biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2hp1, PDBe:2hp1, PDBj:2hp1
PDBsum2hp1
PubMed16954186
UniProtP24630|GSA_SYNP6 Glutamate-1-semialdehyde 2,1-aminomutase (Gene Name=hemL)

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