Structure of PDB 2fpw Chain B Binding Site BS03

Receptor Information

>2fpw Chain B (length=163) Species: 83334 (Escherichia coli O157:H7)

QKYLFIDRDGTLISEPPSDFQVDRFDKLAFEPGVIPQLLKLQKAGYKLVM
ITNQDGLGTQSFPQADFDGPHNLMMQIFTSQGVQFDEVLICPHLPADECD
CRKPKVKLVERYLAEQAMDRANSYVIGDRATDIQLAENMGINGLRYDRET
LNWPMIGEQLTRR

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 2fpw Chain B Residue 505

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2fpw Structural snapshots of Escherichia coli histidinol phosphate phosphatase along the reaction pathway.
• Resolution: 1.75 Å
• Binding residue (original residue number in PDB): X10 D12 D131
• Binding residue (residue number reindexed from 1): X7 D9 D128
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.1.3.15: histidinol-phosphatase.
  4.2.1.19: imidazoleglycerol-phosphate dehydratase.

Gene Ontology

Molecular Function

• GO:0004401 histidinol-phosphatase activity
• GO:0004424 imidazoleglycerol-phosphate dehydratase activity
• GO:0016791 phosphatase activity

Biological Process

• GO:0000105 L-histidine biosynthetic process
• GO:0005975 carbohydrate metabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:2fpw, PDBe:2fpw, PDBj:2fpw
• PDBsum: 2fpw
• PubMed: 16966333
• UniProt: Q9S5G5|HIS7_ECO57 Histidine biosynthesis bifunctional protein HisB (Gene Name=hisB)