Structure of PDB 2ez6 Chain B Binding Site BS03

Receptor Information

>2ez6 Chain B (length=218) Species: 63363 (Aquifex aeolicus)

MLEQLEKKLGYTFKDKSLLEKALTHVSYSKKEHYETLEFLGNALVNFFIV
DLLVQYSPNKREGFLSPLKAYLISEEFFNLLAQKLELHKFIRIKRGKINE
TIIGDVFEALWAAVYIDSGRDANFTRELFYKLFKEDILSAIKEGRVKKDY
KTILQEITQKRWKERPEYRLISVEGPHHKKKFIVEAKIKEYRTLGEGKSK
KEAEQRAAEELIKLLEES

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 2ez6 Chain B Residue 502

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2ez6 Structural Insight into the Mechanism of Double-Stranded RNA Processing by Ribonuclease III.
• Resolution: 2.05 Å
• Binding residue (original residue number in PDB): E40 D107 E110
• Binding residue (residue number reindexed from 1): E38 D105 E108
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.1.26.3: ribonuclease III.

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003725 double-stranded RNA binding
• GO:0004519 endonuclease activity
• GO:0004525 ribonuclease III activity
• GO:0042802 identical protein binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006364 rRNA processing
• GO:0006396 RNA processing
• GO:0006397 mRNA processing
• GO:0008033 tRNA processing
• GO:0010468 regulation of gene expression

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:2ez6, PDBe:2ez6, PDBj:2ez6
• PDBsum: 2ez6
• PubMed: 16439209
• UniProt: O67082|RNC_AQUAE Ribonuclease 3 (Gene Name=rnc)