Structure of PDB 2erq Chain B Binding Site BS03

Receptor Information

>2erq Chain B (length=423) Species: 8730 (Crotalus atrox) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

LTPEQQRYLNAKKYVKLFLVADYIMYLKYGRNLTAVRTRMYDIVNVITPI
YHRMNIHVALVGLEIWSNTDKIIVQSSADVTLDLFAKWRATDLLSRKSHD
NAQLLTGINFNGPTAGLGYLGGICNTMYSAGIVQDHSKIHHLVAIAMAHE
MGHNLGMDHDKDTCTCGTRPCVMAGALSCEASFLFSDCSQKDHREFLIKN
MPQCILKKPLKTDVVSPAVCGNYFVEVGEECDCGSPRTCRDPCCDATTCK
LRQGAQCAEGLCCDQCRFKGAGTECRAAKDECDMADVCTGRSAECTDRFQ
RNGQPCKNNNGYCYNGKCPIMADQCIALFGPGATVSQDACFQFNREGNHY
GYCRKEQNTKIACEPQDVKCGRLYCFPNSPENKNPCNIYYSPNDEDKGMV
LPGTKCADRKACSNGQCVDVTTP

Ligand information

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

2erq Chain B Residue 702 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	2erq Crystal structures of VAP1 reveal ADAMs' MDC domain architecture and its unique C-shaped scaffold
Resolution	2.5 Å
Binding residue (original residue number in PDB)	D469 M470 D472 D483 R484
Binding residue (residue number reindexed from 1)	D283 M284 D286 D297 R298
Annotation score	4

Enzymatic activity

Enzyme Commision number

3.4.24.-

Gene Ontology

	Molecular Function
GO:0004222	metalloendopeptidase activity
GO:0008237	metallopeptidase activity

	Biological Process
GO:0006508	proteolysis

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:2erq, PDBe:2erq, PDBj:2erq
PDBsum	2erq
PubMed	16688218
UniProt	Q9DGB9\|VM3V1_CROAT Zinc metalloproteinase-disintegrin-like VAP1

[Back to BioLiP]