Structure of PDB 2erp Chain B Binding Site BS03

Receptor Information

>2erp Chain B (length=426) Species: 8730 (Crotalus atrox) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SNLTPEQQRYLNAKKYVKLFLVADYIMYLKYGRNLTAVRTRMYDIVNVIT
PIYHRMNIHVALVGLEIWSNTDKIIVQSSADVTLDLFAKWRATDLLSRKS
HDNAQLLTGINFNGPTAGLGYLGGICNTMYSAGIVQDHSKIHHLVAIAMA
HEMGHNLGMDHDKDTCTCGTRPCVMAGALSCEASFLFSDCSQKDHREFLI
KNMPQCILKKPLKTDVVSPAVCGNYFVEVGEECDCGSPRTCRDPCCDATT
CKLRQGAQCAEGLCCDQCRFKGAGTECRAAKDECDMADVCTGRSAECTDR
FQRNGQPCKNNNGYCYNGKCPIMADQCIALFGPGATVSQDACFQFNREGN
HYGYCRKEQNTKIACEPQDVKCGRLYCFPNSPENKNPCNIYYSPNDEDKG
MVLPGTKCADRKACSNGQCVDVTTPY

Ligand information

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

2erp Chain B Residue 702 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	2erp Crystal structures of VAP1 reveal ADAMs' MDC domain architecture and its unique C-shaped scaffold
Resolution	2.95 Å
Binding residue (original residue number in PDB)	D469 M470 D472 D483 R484
Binding residue (residue number reindexed from 1)	D285 M286 D288 D299 R300
Annotation score	4

Enzymatic activity

Enzyme Commision number

3.4.24.-

Gene Ontology

	Molecular Function
GO:0004222	metalloendopeptidase activity
GO:0008237	metallopeptidase activity

	Biological Process
GO:0006508	proteolysis

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:2erp, PDBe:2erp, PDBj:2erp
PDBsum	2erp
PubMed	16688218
UniProt	Q9DGB9\|VM3V1_CROAT Zinc metalloproteinase-disintegrin-like VAP1

[Back to BioLiP]