Structure of PDB 2ebs Chain B Binding Site BS03

Receptor Information
>2ebs Chain B (length=771) Species: 203496 (Geotrichum sp. M128) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HYEFKNVAIGGGGYITGIVAHPKTKDLLYARTDIGGAYRWDAGTSKWIPL
NDFIEAQDMNIMGTESIALDPNNPDRLYLAQGRYVGDEWAAFYVSEDRGQ
SFTIYESPFPMGANDMGRNNGERLAVNPFNSNEVWMGTRTEGIWKSSDRA
KTWTNVTSIPDAFTNGIGYTSVIFDPERNGTIYASATAPQGMYVTHDGGV
SWEPVAGQPSSWLNRTTGAFPDKKPASIAPQPMKVALTPNFLYVTYADYP
GPWGVTFGEVWRQNRTSGAWDDITPRVGNSSPAPYNNQTFPAGGFCGLSV
DATNPNRLVVITLDRDPGPALDSIYLSTDAGATWKDVTQLSSPSNLEGNW
GHPTNAARYKDGTPVPWLDFNNGPQWGGYGAPHGTPGLTKFGWWMSAVLI
DPFNPEHLMYGTGATIWATDTLSRVEKDWAPSWYLQIDGIEENAILSLRS
PKSGAALLSGIGNISGMKHDDLTKPQKMFGAPQFSNLDSIDAAGNFPNVV
VRAGSSGHEYDSACARGAYATDGGDAWTIFPTCPPGMNASHYQGSTIAVD
ASGSQIVWSTKLDEQASGPWYSHDYGKTWSVPAGDLKAQTANVLSDKVQD
GTFYATDGGKFFVSTDGGKSYAAKGAGLVTGTSLMPAVNPWVAGDVWVPV
PEGGLFHSTDFGASFTRVGTANATLVSVGAPKSSAPSAVFIWGTDKPGSD
IGLYRSDDNGSTWTRVNDQEHNYSGPTMIEADPKVYGRVYLGTNGRGIVY
ADLTKSTAKCANGQKGTHCYV
Ligand information
Ligand IDBGC
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6-/m1/s1
InChIKeyWQZGKKKJIJFFOK-VFUOTHLCSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6C(C1C(C(C(C(O1)O)O)O)O)O
CACTVS 3.370OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O
CACTVS 3.370OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
OpenEye OEToolkits 1.7.6C([C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)O)O)O)O)O
ACDLabs 12.01OC1C(O)C(OC(O)C1O)CO
FormulaC6 H12 O6
Namebeta-D-glucopyranose;
beta-D-glucose;
D-glucose;
glucose
ChEMBLCHEMBL1614854
DrugBankDB02379
ZINCZINC000003833800
PDB chain2ebs Chain D Residue 3 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2ebs The Structural Basis for the Exo-mode of Action in GH74 Oligoxyloglucan Reducing End-specific Cellobiohydrolase.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		D35 I36 N116 R120 N465
Binding residue
(residue number reindexed from 1)		D33 I34 N114 R118 N463
Annotation score4
Enzymatic activity
Enzyme Commision number 3.2.1.150: oligoxyloglucan reducing-end-specific cellobiohydrolase.
Gene Ontology
Molecular Function
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0033945 oligoxyloglucan reducing-end-specific cellobiohydrolase activity
Biological Process
GO:0010411 xyloglucan metabolic process
GO:0030245 cellulose catabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2ebs, PDBe:2ebs, PDBj:2ebs
PDBsum2ebs
PubMed17498741
UniProtQ8J0D2|CBHRE_GEOS1 Oligoxyloglucan reducing end-specific cellobiohydrolase

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