Structure of PDB 2b50 Chain B Binding Site BS03

Receptor Information
>2b50 Chain B (length=263) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGHTAPFVIHDIETLWQ
AEKGLVWKLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLN
DQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSD
IIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDT
ILRALEFHLQANHPDAQQLFPKLLQKMADLRQLVTEHAQMMQRIKKTETE
TSLHPLLQEIYKD
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain2b50 Chain B Residue 2303 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2b50 Recombinant Human PPAR-beta/delta Ligand-binding Domain is Locked in an Activated Conformation by Endogenous Fatty Acids
Resolution2.0 Å
Binding residue
(original residue number in PDB)		E407 Q410
Binding residue
(residue number reindexed from 1)		E195 Q198
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2b50, PDBe:2b50, PDBj:2b50
PDBsum2b50
PubMed16405912
UniProtQ03181|PPARD_HUMAN Peroxisome proliferator-activated receptor delta (Gene Name=PPARD)

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