Structure of PDB 1zab Chain B Binding Site BS03

Receptor Information
>1zab Chain B (length=134) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VEPEHVQRLLLSSREAKKSAYCPYSRFPVGAALLTGDGRIFSGCNIENAC
YPLGVCAERTAIQKAISEGYKDFRAIAISSDLQEEFISPCGACRQVMREF
GTDWAVYMTKPDGTFVVRTVQELLPASFGPEDLQ
Ligand information
Ligand IDURD
InChIInChI=1S/C10H13NO6/c12-4-6-8(15)9(16)10(17-6)11-2-1-5(13)3-7(11)14/h1-2,6,8-10,12,15-16H,3-4H2/t6-,8-,9-,10-/m1/s1
InChIKeyWIRVQQCUKDPURA-PEBGCTIMSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C1C(=O)C=CN(C1=O)C2C(C(C(O2)CO)O)O
OpenEye OEToolkits 1.5.0C1C(=O)C=CN(C1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O
ACDLabs 10.04O=C1C=CN(C(=O)C1)C2OC(C(O)C2O)CO
CACTVS 3.341OC[CH]1O[CH]([CH](O)[CH]1O)N2C=CC(=O)CC2=O
CACTVS 3.341OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=CC(=O)CC2=O
FormulaC10 H13 N O6
Name1-((2R,3R,4S,5R)-TETRAHYDRO-3,4-DIHYDROXY-5-(HYDROXYMETHYL)FURAN-2-YL)PYRIDINE-2,4(1H,3H)-DIONE;
3-DEAZAURIDINE
ChEMBL
DrugBank
ZINC
PDB chain1zab Chain D Residue 1004 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1zab The 1.48 A Resolution Crystal Structure of the Homotetrameric Cytidine Deaminase from Mouse
Resolution2.36 Å
Binding residue
(original residue number in PDB)		A58 C59 Y60 P61
Binding residue
(residue number reindexed from 1)		A49 C50 Y51 P52
Annotation score2
Enzymatic activity
Enzyme Commision number 3.5.4.5: cytidine deaminase.
Gene Ontology
Molecular Function
GO:0001882 nucleoside binding
GO:0003824 catalytic activity
GO:0004126 cytidine deaminase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0019239 deaminase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0006248 CMP catabolic process
GO:0006249 dCMP catabolic process
GO:0009972 cytidine deamination
GO:0030308 negative regulation of cell growth
GO:0044206 UMP salvage
GO:0045980 negative regulation of nucleotide metabolic process
GO:0046898 response to cycloheximide
GO:0055086 nucleobase-containing small molecule metabolic process
GO:0071217 cellular response to external biotic stimulus
GO:0072527 pyrimidine-containing compound metabolic process
GO:1901135 carbohydrate derivative metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1zab, PDBe:1zab, PDBj:1zab
PDBsum1zab
PubMed16784234
UniProtP56389|CDD_MOUSE Cytidine deaminase (Gene Name=Cda)

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