Structure of PDB 1w23 Chain B Binding Site BS03

Receptor Information
>1w23 Chain B (length=357) Species: 1445 (Alkalihalobacillus alcalophilus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VKQVFNFNAGPSALPKPALERAQKELLNFNDTQMSVMELSHRSQSYEEVH
EQAQNLLRELLQIPNDYQILFLQGGASLQFTMLPMNLLTKGTIGNYVLTG
SWSEKALKEAKLLGETHIAASTKANSYQSIPDFSEFQLNENDAYLHITSN
NTIYGTQYQNFPEINHAPLIADMSSDILSRPLKVNQFGMIYAGAQKNLGP
SGVTVVIVKKDLLVEQVPTMLQYATHIKSDSLYNTPPTFSIYMLRNVLDW
IKDLGGAEAIAKQNEEKAKIIYDTIDESNGFYVGHAEKGSRSLMNVTFNL
RNEELNQQFLAKAKEQGFVGLNGHRSVGGCRASIYNAVPIDACIALRELM
IQFKENA
Ligand information
Ligand IDPLP
InChIInChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChIKeyNGVDGCNFYWLIFO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O
OpenEye OEToolkits 1.5.0Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O
ACDLabs 10.04O=P(O)(O)OCc1cnc(c(O)c1C=O)C
FormulaC8 H10 N O6 P
NamePYRIDOXAL-5'-PHOSPHATE;
VITAMIN B6 Phosphate
ChEMBLCHEMBL82202
DrugBankDB00114
ZINCZINC000001532514
PDB chain1w23 Chain B Residue 1368 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1w23 Enzyme Adaptation to Alkaline Ph: Atomic Resolution (1.08 A) Structure of Phosphoserine Aminotransferase from Bacillus Alcalophilus
Resolution1.08 Å
Binding residue
(original residue number in PDB)		A76 S77 W102 T152 D172 S174 Q195 K196
Binding residue
(residue number reindexed from 1)		A76 S77 W102 T152 D172 S174 Q195 K196
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) W102 D172 K196
Catalytic site (residue number reindexed from 1) W102 D172 K196
Enzyme Commision number 2.6.1.52: phosphoserine transaminase.
Gene Ontology
Molecular Function
GO:0004648 O-phospho-L-serine:2-oxoglutarate aminotransferase activity
GO:0008483 transaminase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0006563 L-serine metabolic process
GO:0006564 L-serine biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1w23, PDBe:1w23, PDBj:1w23
PDBsum1w23
PubMed15608117
UniProtQ9RME2|SERC_ALKAL Phosphoserine aminotransferase (Gene Name=serC)

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