Structure of PDB 1lqp Chain B Binding Site BS03

Receptor Information
>1lqp Chain B (length=134) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MLTGLNHLTLAVADLPASIAFYRDLLGFRLEARWDQGAYLELGSLWLCLS
REPQYGGPAADYTHYAFGIAAADFARFAAQLRAHGVREWKQNRSEGDSFY
FLDPDGHRLEAHVGDLRSRLAACRQAPYAGMRFA
Ligand information
Ligand IDFCN
InChIInChI=1S/C3H7O4P/c1-2-3(7-2)8(4,5)6/h2-3H,1H3,(H2,4,5,6)/t2-,3+/m0/s1
InChIKeyYMDXZJFXQJVXBF-STHAYSLISA-N
SMILES
SoftwareSMILES
CACTVS 3.341C[C@@H]1O[C@@H]1[P](O)(O)=O
OpenEye OEToolkits 1.5.0C[C@H]1[C@H](O1)P(=O)(O)O
ACDLabs 10.04O=P(O)(O)C1OC1C
OpenEye OEToolkits 1.5.0CC1C(O1)P(=O)(O)O
CACTVS 3.341C[CH]1O[CH]1[P](O)(O)=O
FormulaC3 H7 O4 P
NameFOSFOMYCIN;
1,2-EPOXYPROPYLPHOSPHONIC ACID
ChEMBLCHEMBL1757
DrugBankDB00828
ZINCZINC000001530427
PDB chain1lqp Chain B Residue 4001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1lqp Crystal structure of a genomically encoded fosfomycin resistance protein (FosA) at 1.19 A resolution by MAD phasing off the L-III edge of Tl(+)
Resolution1.19 Å
Binding residue
(original residue number in PDB)		H64 S94 Y100 E110 R119
Binding residue
(residue number reindexed from 1)		H64 S94 Y100 E110 R119
Annotation score1
Enzymatic activity
Enzyme Commision number 2.5.1.18: glutathione transferase.
Gene Ontology
Molecular Function
GO:0004364 glutathione transferase activity
GO:0016740 transferase activity
GO:0046872 metal ion binding
Biological Process
GO:0046677 response to antibiotic
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1lqp, PDBe:1lqp, PDBj:1lqp
PDBsum1lqp
PubMed12224946
UniProtQ9I4K6|FOSA_PSEAE Glutathione transferase FosA (Gene Name=fosA)

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