Structure of PDB 1jjt Chain B Binding Site BS03

Receptor Information

>1jjt Chain B (length=220) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

ESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPF
TAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASEL
TNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPER
KILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVG
DASLLKLTLEQAVKGLNESK

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

1jjt Chain B Residue 261 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1jjt Succinic acids as potent inhibitors of plasmid-borne IMP-1 metallo-beta-lactamase.
Resolution	1.8 Å
Binding residue (original residue number in PDB)	H34 E199
Binding residue (residue number reindexed from 1)	H33 E198
Annotation score	1

Enzymatic activity

Catalytic site (original residue number in PDB)	H77 H79 D81 H139 C158 K161 N167 H197
Catalytic site (residue number reindexed from 1)	H76 H78 D80 H138 C157 K160 N166 H196
Enzyme Commision number	3.5.2.6: beta-lactamase.

Gene Ontology

	Molecular Function
GO:0008270	zinc ion binding
GO:0008800	beta-lactamase activity
GO:0016787	hydrolase activity
GO:0046872	metal ion binding

	Biological Process
GO:0017001	antibiotic catabolic process
GO:0046677	response to antibiotic

	Cellular Component
GO:0042597	periplasmic space

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Cellular Component

External links

PDB	RCSB:1jjt, PDBe:1jjt, PDBj:1jjt
PDBsum	1jjt
PubMed	11390410
UniProt	Q79MP6

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