Structure of PDB 1htb Chain B Binding Site BS03
Receptor Information
>1htb Chain B (length=374) Species:
9606
(Homo sapiens) [
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STAGKVIKCKAAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICRTDD
HVVSGNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKC
RVCKNPESNYCLKNDLGNPRGTLQDGTRRFTCRGKPIHHFLGTSTFSQYT
VVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFGL
GGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPI
QEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQN
LSINPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVL
PFEKINEGFDLLHSGKSICTVLTF
Ligand information
Ligand ID
NAD
InChI
InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1
InChIKey
BAWFJGJZGIEFAR-NNYOXOHSSA-N
SMILES
Software
SMILES
CACTVS 3.341
NC(=O)c1ccc[n+](c1)[C@@H]2O[C@H](CO[P]([O-])(=O)O[P@](O)(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n4cnc5c(N)ncnc45)[C@@H](O)[C@H]2O
OpenEye OEToolkits 1.5.0
c1cc(c[n+](c1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)n4cnc5c4ncnc5N)O)O)O)O)C(=O)N
CACTVS 3.341
NC(=O)c1ccc[n+](c1)[CH]2O[CH](CO[P]([O-])(=O)O[P](O)(=O)OC[CH]3O[CH]([CH](O)[CH]3O)n4cnc5c(N)ncnc45)[CH](O)[CH]2O
OpenEye OEToolkits 1.5.0
c1cc(c[n+](c1)[C@H]2[C@@H]([C@@H]([C@H](O2)CO[P@@](=O)([O-])O[P@@](=O)(O)OC[C@@H]3[C@H]([C@H]([C@@H](O3)n4cnc5c4ncnc5N)O)O)O)O)C(=O)N
Formula
C21 H27 N7 O14 P2
Name
NICOTINAMIDE-ADENINE-DINUCLEOTIDE
ChEMBL
CHEMBL1234613
DrugBank
DB14128
ZINC
PDB chain
1htb Chain B Residue 377 [
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Receptor-Ligand Complex Structure
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PDB
1htb
X-ray structure of human beta3beta3 alcohol dehydrogenase. The contribution of ionic interactions to coenzyme binding.
Resolution
2.4 Å
Binding residue
(original residue number in PDB)
C46 R47 T48 H51 C174 T178 G201 V203 D223 K228 I269 R271 V292 G293 V294 V318
Binding residue
(residue number reindexed from 1)
C46 R47 T48 H51 C174 T178 G201 V203 D223 K228 I269 R271 V292 G293 V294 V318
Annotation score
4
Binding affinity
MOAD
: Kd=670uM
Enzymatic activity
Catalytic site (original residue number in PDB)
C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 C369
Catalytic site (residue number reindexed from 1)
C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 C369
Enzyme Commision number
1.1.1.105
: all-trans-retinol dehydrogenase (NAD(+)).
Gene Ontology
Molecular Function
GO:0004022
alcohol dehydrogenase (NAD+) activity
GO:0004745
all-trans-retinol dehydrogenase (NAD+) activity
GO:0005515
protein binding
GO:0008270
zinc ion binding
GO:0016491
oxidoreductase activity
GO:0046872
metal ion binding
Biological Process
GO:0001523
retinoid metabolic process
GO:0006629
lipid metabolic process
GO:0042572
retinol metabolic process
GO:0042573
retinoic acid metabolic process
Cellular Component
GO:0005654
nucleoplasm
GO:0005737
cytoplasm
GO:0005829
cytosol
GO:0005886
plasma membrane
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Cellular Component
External links
PDB
RCSB:1htb
,
PDBe:1htb
,
PDBj:1htb
PDBsum
1htb
PubMed
8663387
UniProt
P00325
|ADH1B_HUMAN All-trans-retinol dehydrogenase [NAD(+)] ADH1B (Gene Name=ADH1B)
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