Structure of PDB 1ekb Chain B Binding Site BS03

Receptor Information
>1ekb Chain B (length=235) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVGGSDSREGAWPWVVALYFDDQQVCGASLVSRDWLVSAAHCVYGRNMEP
SKWKAVLGLHMASNLTSPQIETRLIDQIVINPHYNKRRKNNDIAMMHLEM
KVNYTDYIQPICLPEENQVFPPGRICSIAGWGALIYQGSTADVLQEADVP
LLSNEKCQQQMPEYNITENMVCAGYEAGGVDSCQGDSGGPLMCQENNRWL
LAGVTSFGYQCALPNRPGVYARVPRFTEWIQSFLH
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1ekb Chain B Residue 310 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1ekb Crystal structure of enteropeptidase light chain complexed with an analog of the trypsinogen activation peptide.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		H57 E126 S195
Binding residue
(residue number reindexed from 1)		H41 E116 S187
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 Q192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H41 D92 Q184 G185 D186 S187 G188
Enzyme Commision number 3.4.21.9: enteropeptidase.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1ekb, PDBe:1ekb, PDBj:1ekb
PDBsum1ekb
PubMed10493881
UniProtP98072|ENTK_BOVIN Enteropeptidase (Gene Name=TMPRSS15)

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