Structure of PDB 1cgl Chain B Binding Site BS03

Receptor Information

>1cgl Chain B (length=157) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

NPRWEQTHLRYRIENYTPDLPRADVDHAIEKAFQLWSDVTPLTFTKVQAD
IMISFVRGDHRDNSPFDGPGGNLAHAFDPGPGIGGDAHFDEDERWTNNFR
EYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQA
IYGRSQN

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

1cgl Chain B Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1cgl Structure of the catalytic domain of fibroblast collagenase complexed with an inhibitor.
Resolution	2.4 Å
Binding residue (original residue number in PDB)	H168 D170 H183 H196
Binding residue (residue number reindexed from 1)	H60 D62 H75 H88
Annotation score	4

Enzymatic activity

Catalytic site (original residue number in PDB)	H218 E219 H222 H228
Catalytic site (residue number reindexed from 1)	H110 E111 H114 H120
Enzyme Commision number	3.4.24.7: interstitial collagenase.

Gene Ontology

	Molecular Function
GO:0004222	metalloendopeptidase activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

	Biological Process
GO:0006508	proteolysis

	Cellular Component
GO:0031012	extracellular matrix

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Molecular Function

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Cellular Component

External links

PDB	RCSB:1cgl, PDBe:1cgl, PDBj:1cgl
PDBsum	1cgl
PubMed	8278810
UniProt	P03956\|MMP1_HUMAN Interstitial collagenase (Gene Name=MMP1)

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