Structure of PDB 8oip Chain Aa Binding Site BS03

Receptor Information
>8oip Chain Aa (length=381) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DTKMLWKHKALQKYMENLSKEYQTLEQCLQHIPVNEENRRSLNRRHAELA
PLAAIYQEIQETEQAIEELESMCKSLNKQDEKQLQELALEERQTIDQKIN
MLYNELFQSLVPKEKYDKNDVILEVTAGRTTGGDICQQFTREIFDMYQNY
SCYKHWQFELLNYTPADYGGLHHAAARISGDGVYKHLKYEGGIHRVQRIP
EVGLSSRMQRIHTGTMSVIVLPQPDEVDVKLDPKDLRIDTFRAKGAGGQH
VNKTDSAVRLVHIPTGLVVECQQERSQIKNKEIAFRVLRARLYQQIIEKD
KRQQQSARKLQVGTRAQSERIRTYNFTQDRVSDHRIAYEVRDIKEFLCGG
KGLDQLIQRLLQSADEEAIAELLDEHLKSAK
Ligand information
Receptor-Ligand Complex Structure
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PDB8oip Molecular basis of translation termination at noncanonical stop codons in human mitochondria.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		T195 G197 Q261 S269 R271 M272 R274 I275 H276 T277
Binding residue
(residue number reindexed from 1)		T131 G133 Q197 S205 R207 M208 R210 I211 H212 T213
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003747 translation release factor activity
GO:0016149 translation release factor activity, codon specific
Biological Process
GO:0006412 translation
GO:0006415 translational termination
GO:0070126 mitochondrial translational termination
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8oip, PDBe:8oip, PDBj:8oip
PDBsum8oip
PubMed37141370
UniProtO75570|RF1M_HUMAN Peptide chain release factor 1, mitochondrial (Gene Name=MTRF1)

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