Structure of PDB 8hl3 Chain AEFG Binding Site BS03

Receptor Information
>8hl3 Chain AEFG (length=725) Species: 330779 (Sulfolobus acidocaldarius DSM 639) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VEQVLSLMKDVTRVRNIGIIAHVDHGKTTTSDTLLAASGIISQEALALDY
LSVEQQRGITVKAANISLYHEIDGKGYVINLIDTPGHVDFSGRVTRSLRV
LDGSIVVIDAVEGIMTQTETVLRQSLEERVRPILFINKVDRLIKELKLSS
QEIQKRLIDLIIEVNNLIETYGEPEFKDQWKIKPELGNVVFGSAKDKWGF
SVPMAGKRGVKFSDVVNAYTSGDKAKIEELASKVPIHEALLDAVIKFVPN
PRDSQKYRIPKIWKGDLDSEIAKAMINADPNGPIVMMINDMKVDPHAGLV
ATGRVFSGTLRAGEEVWLVNAKRQQRILQVSLYMGAIRELAEEIPVGNIA
AALGMDAARSGETGVDIRFKDSVLGSFEKLHYISEPVVTISVEPRNPKDL
TKMIDALRKLSIEDSNLVVKINEETGEYLLSGMGFLHLEVSLQLLKENYG
LDVVTTPPIVVYRESIRNKSQVFEGKSPNKHNKLYISVEPLNNQTIDLIA
NGTIKEDMDNKEMAKILRDQAEWDYDEAKKIVAIDENINVFIDATSGVQH
LREIMDTLLQGFRLAMKEGPLAFEPVRGVKVVLHDAVVHEDPAHRGPAQL
YPAVRNAIFAGILTSKPTLLEPLQKLDIRIPMEYLGNVTAVITRKRGKVI
NVVQTGNVARVYAEIPVGESFELASELRASSAGRAFWGTEFSRWAPVPDS
ILVDLIMKIRERKGKPKQLPKVEDF
Ligand information
Ligand IDGNP
InChIInChI=1S/C10H17N6O13P3/c11-10-13-7-4(8(19)14-10)12-2-16(7)9-6(18)5(17)3(28-9)1-27-32(25,26)29-31(23,24)15-30(20,21)22/h2-3,5-6,9,17-18H,1H2,(H,25,26)(H3,11,13,14,19)(H4,15,20,21,22,23,24)/t3-,5-,6-,9-/m1/s1
InChIKeyUQABYHGXWYXDTK-UUOKFMHZSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=P(O)(O)NP(=O)(O)OP(=O)(O)OCC3OC(n2cnc1c2N=C(N)NC1=O)C(O)C3O
OpenEye OEToolkits 1.5.0c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)O[P@@](=O)(NP(=O)(O)O)O)O)O)N=C(NC2=O)N
OpenEye OEToolkits 1.5.0c1nc2c(n1C3C(C(C(O3)COP(=O)(O)OP(=O)(NP(=O)(O)O)O)O)O)N=C(NC2=O)N
CACTVS 3.341NC1=Nc2n(cnc2C(=O)N1)[C@@H]3O[C@H](CO[P@@](O)(=O)O[P@@](O)(=O)N[P](O)(O)=O)[C@@H](O)[C@H]3O
CACTVS 3.341NC1=Nc2n(cnc2C(=O)N1)[CH]3O[CH](CO[P](O)(=O)O[P](O)(=O)N[P](O)(O)=O)[CH](O)[CH]3O
FormulaC10 H17 N6 O13 P3
NamePHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
ChEMBLCHEMBL1233085
DrugBankDB02082
ZINCZINC000037868676
PDB chain8hl3 Chain AEFG Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8hl3 Cryo-EM Structures and Translocation Mechanism of Crenarchaeota Ribosome
Resolution4.8 Å
Binding residue
(original residue number in PDB)		V29 D30 G32 K33 T34 T35 Q65 Q66 R67 G68 I69 P95 K148 D150 K205
Binding residue
(residue number reindexed from 1)		V23 D24 G26 K27 T28 T29 Q55 Q56 R57 G58 I59 P85 K138 D140 K195
Annotation score3
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0006412 translation
GO:0006414 translational elongation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8hl3, PDBe:8hl3, PDBj:8hl3
PDBsum8hl3
PubMed37604686
UniProtP23112|EF2_SULAC Elongation factor 2 (Gene Name=fusA)

[Back to BioLiP]