Structure of PDB 9bs3 Chain A Binding Site BS03

Receptor Information

>9bs3 Chain A (length=627) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

DPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIEEVSARLRMVET
LSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLELGVGDGVLLKAVAQA
TGRQLESVRAEAAEKGDVGLVAENSRSPPPPLTASGVFSKFRDIARLTGS
ASTAKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLAALSQAV
SLTPPGQEFPPAMVDAGKGKTAEARKTWLEEQGMILKQTFCEVPDLDRII
PVLLEHGLERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRFEEAAFTCEY
KYDGQRAQIHALEGGEVKIFSRNQEDNTGKYPDIISRIPKIKLPSVTSFI
LDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAFDLIYLNG
ESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFLEQSVKD
SCEGLMVKTLDVDATYEIAKRSHNWLKLKKDDTLDLVVIGAYLGRGKRAG
RYGGFLLASYDEDSEELQAICKLGTGFSDEELEEHHQSLKALVLPSPRPY
VRIDGAVIPDHWLDPSAVWEVKCADLSLSPIYPAARGLVDSDKGISLRFP
RFIRVREDKQPEQATTSAQVACLYRKQ

Ligand information

>9bs3 Chain D (length=18) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

gtccgaccacgcatcagc

Receptor-Ligand Complex Structure

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Structure summary

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PDB	9bs3 Structures of LIG1 uncover the mechanism of sugar discrimination against 5'-RNA-DNA junctions during ribonucleotide excision repair.
Resolution	2.69 Å
Binding residue (original residue number in PDB)	T415 G416 S417 A418 S419 T420 R451 L452 G453 A455 Q457 S458 R557 Q636 T639 T640 K642 R643 K644 H740
Binding residue (residue number reindexed from 1)	T148 G149 S150 A151 S152 T153 R184 L185 G186 A188 Q190 S191 R290 Q369 T372 T373 K375 R376 K377 H473

External links

PDB	RCSB:9bs3, PDBe:9bs3, PDBj:9bs3
PDBsum	9bs3
PubMed	39159820
UniProt	P18858\|DNLI1_HUMAN DNA ligase 1 (Gene Name=LIG1)

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