Structure of PDB 8xc1 Chain A Binding Site BS03

Receptor Information
>8xc1 Chain A (length=660) Species: 6239 (Caenorhabditis elegans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NSSVLVFEISSKMKMIEKKLEANTVHVLRLELDQSFILDLTKVAAEIVDS
SKYSKEDGVILEVTVSNGRDSFLLKLPTVYPNLKLYTDGKLLNPLVEQDF
GAHRKRHRIGDPHFHQNLIVTVQSRLNADIDYRLHVTHLDRAQYDFLKFK
TGQTTKTLSNQKLTFVKPIGFFLNCSEQNISQFHVTLYSEDDICANLITV
PANESIYDRSVISDKTHNRRVLSFTKRADIFFTETEISMFKSFRIFVFIA
PDDSGCSTNTSRKSFNEKKKISFEFKKLENQSYAVPTALMMIFLTTPCLL
FLPIVINIIKNSSLHGQMLQYPVAIILPVLMHTAIEFHKWTTSTMANRDE
MCFHNHACARPLGELRAWNNIITNIGYTLYGAIFIVLSICRRGSHVFGTY
ECTLLDVTIGVFMVLQSIASATYHICPSDVAFQFDTPCIQVICGLLMVRQ
WFVRHESPSPAYTNILLVGVVSLNFLISAFSKTSYVRFIIAVIHVIVVGS
ICLAKERSLGSEKLKTRFFIMAFSMGNFAAIVMYLTLSAFHLNQIATYCF
IINCIMYLMYYGCMKVLHSERITSKAKLCGALSLLAWAVAGFFFFQDDTD
WTRSAAASRALNKPCLLLGFFGSHDLWHIFGALAGLFTFIFVSFVDDDLI
NTRKTSINIF
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8xc1 Chain A Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8xc1 Structural basis for double-stranded RNA recognition by SID1.
Resolution2.21 Å
Binding residue
(original residue number in PDB)		H540 D551 H740 H744
Binding residue
(residue number reindexed from 1)		H424 D435 H624 H628
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0051033 RNA transmembrane transporter activity
Biological Process
GO:0031047 regulatory ncRNA-mediated gene silencing
GO:0033227 dsRNA transport
GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing
GO:0050658 RNA transport
Cellular Component
GO:0005764 lysosome
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8xc1, PDBe:8xc1, PDBj:8xc1
PDBsum8xc1
PubMed38742627
UniProtQ9GZC8|SID1_CAEEL Systemic RNA interference defective protein 1 (Gene Name=sid-1)

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