Structure of PDB 8wuv Chain A Binding Site BS03 |
| >8wuv Chain A (length=1326) Species: 301447 (Streptococcus pyogenes serotype M1)
[Search protein sequence]
[Download receptor structure]
[Download structure with residue number starting from 1]
[View receptor structure]
|
DKKYSIGLAIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGAL
LFDSGETAEATRLKRTARRRYTRRKNRICYLQEIFSNEMAKVDDSFFHRL
EESFLVEEDKKHERHPIFGNIVDEVAYHEKYPTIYHLRKKLVDSTDKADL
RLIYLALAHMIKFRGHFLIEGDLNPDNSDVDKLFIQLVQTYNQLFEENPI
NASGVDAKAILSARLSKSRRLENLIAQLPGEKKNGLFGNLIALSLGLTPN
FKSNFDLAEDAKLQLSKDTYDDDLDNLLAQIGDQYADLFLAAKNLSDAIL
LSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQLPEKYKEIF
FDQSKNGYAGYIDGGASQEEFYKFIKPILEKMDGTEELLVKLNREDLLRK
QRTFDNGSIPHQIHLGELHAILRRQEDFYPFLKDNREKIEKILTFRIPYY
VGPLARGNSRFAWMTRKSEETITPWNFEEVVDKGASAQSFIERMTNFDKN
LPNEKVLPKHSLLYEYFTVYNELTKVKYVTEGMRKPAFLSGEQKKAIVDL
LFKTNRKVTVKQLKEDYFKKIECFDSVEISGVEDRFNASLGTYHDLLKII
KDKDFLDNEENEDILEDIVLTLTLFEDREMIEERLKTYAHLFDDKVMKQL
KRRRYTGWGRLSRKLINGIRDKQSGKTILDFLKSDGFANRNFMQLIHDDS
LTFKEDIQKAQVSGQGDSLHEHIANLAGSPAIKKGILQTVKVVDELVKVM
GRHKPENIVIEMARENSRERMKRIEEGIKELGSQILKEHPVENTQLQNEK
LYLYYLQNGRDMYVDQELDINRLSDYDVDAIVPQSFLKDDSIDNKVLTRS
DKNRGKSDNVPSEEVVKKMKNYWRQLLNAKLITQRKFDNLTKAERGGLSE
LDKAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIREVKVITLKS
KLVSDFRKDFQFYKVREINNYHHAHDAYLNAVVGTALIKKYPKLESEFVY
GKATAKYFFYSNIMNFFKTEIIRKRPLIETNGETGEIVWDKGRDFATVRK
VLSMPQVNIVKKTEVQTGGFSKESILPKRNSDKLIARKKDWDPKKYGGFD
SPTVAYSVLVVAKVEKGKSKKLKSVKELLGITIMERSSFEKNPIDFLEAK
GYKEVKKDLIIKLPKYSLFELENGRKRMLASAGELQKGNELALPSKYVNF
LYLASHYEKPEDNEQKQLFVEQHKHYLDEIIEQISEFSKRVILADANLDK
VLSAYNKHRDKPIREQAENIIHLFTLTNLGAPAAFKYFDTTIDRKRYTST
KEVLDATLIHQSITGLYETRIDLSQL |
|
|
|
| Global view | Local view | Structure summary |
[Spin on]
[Spin off]
[Reset]
[High quality]
[Low quality]
[White background]
[Black background]
|
[Spin on]
[Spin off]
[Reset]
[High quality]
[Low quality]
[White background]
[Black background]
|
| PDB | 8wuv Structural basis for pegRNA-guided reverse transcription by a prime editor. |
| Resolution | 3.0 Å |
Binding residue
(original residue number in PDB) | K30 K31 K33 I43 K44 N46 E57 T58 A59 T62 R63 R66 R69 R70 R71 Y72 R74 R75 K76 N77 L101 S104 F105 K111 R115 H116 I122 H129 T134 I135 H160 K163 F164 R165 G166 Y325 H328 H329 K336 R340 F351 F352 Y359 I363 D364 Q402 R403 T404 F405 N407 G408 F446 R447 I448 Y450 G453 L455 A456 R457 N459 S460 F462 R467 I473 P475 N588 H721 K742 Y981 M1089 P1090 Q1091 E1099 V1100 G1103 G1104 F1105 I1110 P1112 K1113 R1122 K1123 K1124 W1126 Y1131 F1134 M1169 A1227 Q1272 H1349 Q1350 S1351 Y1356 T1358 |
Binding residue
(residue number reindexed from 1) | K29 K30 K32 I42 K43 N45 E56 T57 A58 T61 R62 R65 R68 R69 R70 Y71 R73 R74 K75 N76 L100 S103 F104 K110 R114 H115 I121 H128 T133 I134 H159 K162 F163 R164 G165 Y324 H327 H328 K335 R339 F350 F351 Y358 I362 D363 Q401 R402 T403 F404 N406 G407 F445 R446 I447 Y449 G452 L454 A455 R456 N458 S459 F461 R466 I472 P474 N587 H720 K741 Y971 M1054 P1055 Q1056 E1064 V1065 G1068 G1069 F1070 I1075 P1077 K1078 R1087 K1088 K1089 W1091 Y1096 F1099 M1134 A1192 Q1233 H1310 Q1311 S1312 Y1317 T1319 |
|
|
|
|
|
|
|
|
