Structure of PDB 8wus Chain A Binding Site BS03 |
| >8wus Chain A (length=1313) Species: 301447 (Streptococcus pyogenes serotype M1)
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DKKYSIGLAIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGAL
LFDSGETAEATRLKRTARRRYTRRKNRICYLQEIFSNEMAKVDDSFFHRL
EESFLVEEDKKHERHPIFGNIVDEVAYHEKYPTIYHLRKKLVDSTDKADL
RLIYLALAHMIKFRGHFLIEGDLNPDNSDVDKLFIQLVQTYNQLFEENPI
NASGVDAKAILSARLSKSRRLENLIAQLPGEKKNGLFGNLIALSLGLTPN
FKSNFDLAEDAKLQLSKDTYDDDLDNLLAQIGDQYADLFLAAKNLSDAIL
LSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQLPEKYKEIF
FDQSKNGYAGYIDGGASQEEFYKFIKPILEKMDGTEELLVKLNREDLLRK
QRTFDNGSIPHQIHLGELHAILRRQEDFYPFLKDNREKIEKILTFRIPYY
VGPLARGNSRFAWMTRKSEETITPWNFEEVVDKGASAQSFIERMTNFDKN
LPNEKVLPKHSLLYEYFTVYNELTKVKYVTEGMRKPAFLSGEQKKAIVDL
LFKTNRKVTVKQLKEDYFKKIETYHDLLKIIKDKDFLDNEENEDILEDIV
LTLTLFEDREMIEERLKTYAHLFDDKVMKQLKRRRYTGWGRLSRKLINGI
RDKQSGKTILDFLKSDGFANRNFMQLIHDDSLTFKEDIQKAQVSGQGDSL
HEHIANLAGSPAIKKGILQTVKVVDELVKVMGRHKPENIVIEMAREKNSR
ERMKRIEEGIKELGSQILKEHPVENTQLQNEKLYLYYLQNGRDMYVDQEL
DINRLSDYDVDAIVPQSFLKDDSIDNKVLTRSDKNRGKSDNVPSEEVVKK
MKNYWRQLLNAKLITQRKFDNLTKAERGGLSELDKAGFIKRQLVETRQIT
KHVAQILDSRMNTKYDENDKLIREVKVITLKSKLVSDFRKDFQFYKVREI
NNYHHAHDAYLNAVVGTALIKKYPKLESEFVYGKATAKYFFYSNIMNFFK
TEITIRKRPLIETNGETGEIVWDKGRDFATVRKVLSMPQVNIVKKTEVQT
GGFSKESILPKRNSDKLIARKKDWDPKKYGGFDSPTVAYSVLVVAKVEKG
KSKKLKSVKELLGITIMERSSFEKNPIDFLEAKGYKEVKKDLIIKLPKYS
LFELENGRKRMLASAGELQKGNELALPSKYVNFLYLASHYEKLKGSPEDN
EQKQLFVEQHKHYLDEIIEQISEFSKRVILADANLDKVLSAYNKHRDKPI
REQAENIIHLFTLTNLGAPAAFKYFDTTIDRKRYTSTKEVLDATLIHQSI
TGLYETRIDLSQL |
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| PDB | 8wus Structural basis for pegRNA-guided reverse transcription by a prime editor. |
| Resolution | 2.9 Å |
Binding residue
(original residue number in PDB) | K3 S29 K30 K31 K33 I43 K44 N46 E57 T58 A59 T62 R63 R66 R69 R70 R71 Y72 R74 R75 K76 N77 L101 S104 F105 K111 H116 I122 H129 T134 I135 H160 K163 F164 R165 G166 Y325 H328 H329 L332 K336 R340 F351 Y359 A360 I363 K401 Q402 R403 T404 F405 N407 G408 F446 R447 I448 Y450 L455 A456 R457 N459 S460 F462 W464 R467 I473 H721 K742 K749 R753 Y981 M1089 P1090 Q1091 E1099 V1100 G1103 G1104 F1105 I1110 P1112 K1113 R1122 K1123 K1124 W1126 Y1131 M1169 E1225 A1227 Q1272 H1349 Q1350 S1351 Y1356 |
Binding residue
(residue number reindexed from 1) | K2 S28 K29 K30 K32 I42 K43 N45 E56 T57 A58 T61 R62 R65 R68 R69 R70 Y71 R73 R74 K75 N76 L100 S103 F104 K110 H115 I121 H128 T133 I134 H159 K162 F163 R164 G165 Y324 H327 H328 L331 K335 R339 F350 Y358 A359 I362 K400 Q401 R402 T403 F404 N406 G407 F445 R446 I447 Y449 L454 A455 R456 N458 S459 F461 W463 R466 I472 H701 K722 K729 R733 Y953 M1037 P1038 Q1039 E1047 V1048 G1051 G1052 F1053 I1058 P1060 K1061 R1070 K1071 K1072 W1074 Y1079 M1117 E1173 A1175 Q1220 H1297 Q1298 S1299 Y1304 |
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